Alpha-tocopherol affects androgen metabolism in male rat
| Autor: | Luca Barella, Cristina Rota, Gerald Rimbach, Elisabeth Stöcklin |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class medicine.medical_treatment alpha-Tocopherol Tocopherols Biology Reductase General Biochemistry Genetics and Molecular Biology Gene Expression Regulation Enzymologic chemistry.chemical_compound Farnesyl Pyrophosphate Synthetase History and Philosophy of Science Internal medicine Adrenal Glands Testis medicine Animals Testosterone Cholesterol General Neuroscience Vitamin E Androgen Diet Rats Endocrinology chemistry Androgens lipids (amino acids peptides and proteins) Lipoprotein Hormone |
| Zdroj: | Annals of the New York Academy of Sciences. 1031 |
| ISSN: | 0077-8923 |
| Popis: | The Alpha-Tocopherol Beta-Carotene Cancer Prevention Study has provided the first evidence implicating vitamin E in hormone synthesis. The effect of vitamin E on stereoidogenesis in testes and adrenal glands was assessed in growing rats using Affymetrix gene-chip technology. Dietary supplementation of rats with vitamin E (60 mg/kg feed) for a period of 429 days caused a significant repression of genes encoding for proteins centrally involved in the uptake (low-density lipoprotein receptor) and de novo synthesis (for example, 7-dehydrocholesterol reductase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, isopentenyl-diphosphate delta-isomerase, and farnesyl pyrophosphate synthetase) of cholesterol, the precursor of all steroid hormones. The present investigation indicates that dietary vitamin E may induce changes in stereoidogenesis by affecting cholesterol homeostasis. |
| Databáze: | OpenAIRE |
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