Computer-based Eye-tracking Analysis of King-Devick Test Differentiates Persons With Idiopathic Normal Pressure Hydrocephalus From Cognitively Unimpaired
| Autor: | Juha-Matti Lehtola, Virve Kärkkäinen, Sami Andberg, Sanna Hannonen, Minna Rusanen, Toni Saari, Ville Korhonen, Laura Hokkanen, Merja Hallikainen, Tuomo Hänninen, Kai Kaarniranta, Roman Bednarik, Ville Leinonen, Anne M. Koivisto |
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| Přispěvatelé: | Department of Psychology and Logopedics, University of Helsinki, Department of Neurosciences, Clinicum, Helsinki University Hospital Area, Neurologian yksikkö |
| Rok vydání: | 2022 |
| Předmět: |
3112 Neurosciences
Neuropsychological Tests 3124 Neurology and psychiatry Hydrocephalus Normal Pressure Psychiatry and Mental health Clinical Psychology idiopathic normal pressure hydrocephalus (iNPH) Alzheimer Disease Alzheimer's disease (AD) eye tracking (ET) saccadic eye movements biomarker Humans Geriatrics and Gerontology King-Devick (KD) Eye-Tracking Technology Gerontology Biomarkers |
| Zdroj: | Alzheimer disease and associated disorders. 36(4) |
| ISSN: | 1546-4156 |
| Popis: | Publisher Copyright: © 2022 Lippincott Williams and Wilkins. All rights reserved. Background: Functional defects in eye movements and reduced reading speed in neurodegenerative diseases represent a potential new biomarker to support clinical diagnosis. We investigated whether computer-based eye-tracking (ET) analysis of the King-Devick (KD) test differentiates persons with idiopathic normal pressure hydrocephalus (iNPH) from cognitively unimpaired [control (CO)] and persons with Alzheimer's disease (AD). Methods: We recruited 68 participants (37 CO, 10 iNPH, and 21 AD) who underwent neurological examination, the Consortium to Establish a Registry for Alzheimer's Disease neuropsychological test battery (CERAD-NB), and a Clinical Dementia Rating interview. The KD reading test was performed using computer-based ET. We analyzed the total time used for the reading test, number of errors, durations of fixation and saccade, and saccade amplitudes. Results: The iNPH group significantly differed from the CO group in the KD test mean total time (CO 69.3 s, iNPH 87.3 s; P≤0.009) and eye-tracking recording of the mean saccade amplitude (CO 3.6 degree, iNPH 3.2 degree; P≤0.001). The AD group significantly differed from the CO group in each tested parameter. No significant differences were detected between the iNPH and AD groups. Conclusion: For the first time, we demonstrated altered reading ability and saccade amplitudes in patients with iNPH. |
| Databáze: | OpenAIRE |
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