Comparison of Gd-DTPA and Gd-BOPTA for studying renal perfusion and filtration
| Autor: | Maximilian F. Reiser, K. P. Lodemann, Bente Jespersen, Michael Pedersen, Michael Fischereder, Christian Glaser, Mike Notohamiprodjo, Andreas Helck, Steven Sourbron |
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| Rok vydání: | 2011 |
| Předmět: |
Gadolinium DTPA
Gd bopta Swine Contrast Media Renal function Urine Sensitivity and Specificity Renal Circulation Meglumine Bolus (medicine) medicine.artery Image Interpretation Computer-Assisted Organometallic Compounds medicine Animals Radiology Nuclear Medicine and imaging Renal perfusion Aorta Proteinuria Chemistry business.industry Reproducibility of Results Image Enhancement medicine.symptom Nuclear medicine business Perfusion Blood Flow Velocity Magnetic Resonance Angiography Glomerular Filtration Rate |
| Zdroj: | Notohamiprodjo, M, Pedersen, M, Glaser, C, Helck, A D, Lodemann, K-P, Jespersen, B, Fischereder, M, Reiser, M F & Sourbron, S P 2011, ' Comparison of Gd-DTPA and Gd-BOPTA for studying renal perfusion and filtration ', Journal of Magnetic Resonance Imaging, vol. 34, pp. 595-607 . https://doi.org/10.1002/jmri.22640 |
| ISSN: | 1053-1807 |
| DOI: | 10.1002/jmri.22640 |
| Popis: | Material and Methods: The 2-compartment filtration model for Gd-DTPA (2) was generalized to allow for protein binding. Eight healthy Danish-Landrace-pigs were examined in general anaesthesia at 1.5T with a saturation-recovery TurboFLASH sequence (1 axial and 2 coronal slices; temporal resolution 1s; TR 194ms; TE 0.96ms; IR 9ms; slice thickness 8mm). A double-bolus protocol with Gd-DTPA as first bolus followed by Gd-BOPTA as second bolus or vice versa (group I; Gd-DTPA/Gd-BOPTA n = 4 vs. group II GdBOPTA/Gd-DTPA n = 4) was performed. An arterial input function (AIF) was defined manually in the aorta and cortical regions-ofinterest were defined semi-automatically in left- and right kidneys using thresholds on plasma volume. Data were fitted to the generalized 2-compartment filtration model, producing split renal plasma-flow (FP) and -volume (VP), tubular flow (FT) or glomerular-filtration-rate (GFR) and tubular transit time (TT). Urine protein levels were obtained. Gd-DTPA and Gd-BOPTA values were compared with the Wilcoxon-signed-rank-test. Differences between both groups were assessed with the Wilcoxon-rank-sumtest. Results: The pigs demonstrated a weak proteinuria of 0.27 ± 0.08g/l. There were no significant differences between group I (GdDTPA then Gd-BOPTA) and group II (Gd-BOPTA) for any of the parameters. The AIF measured with Gd-BOPTA showed a significantly higher maximal enhancement (162.8 ± 36.9 AU), compared to the AIF derived from Gd-DTPA (145±29.8 AU) (p |
| Databáze: | OpenAIRE |
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