Reliability of peripheral arterial tonometry in patients with heart failure, diabetic nephropathy and arterial hypertension
| Autor: | Simon Litmeier, Elvis Tahirovic, Burkert Pieske, Sara Radenovic, Andreas Busjahn, Josephine Wagner, Hans-Dirk Düngen, Christine Zelenak, Fabian Weisrock, Wilfried Dinh, Max Fritschka, Thomas Krahn, Djawid Hashemi, Sebastian Beckmann |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Diabetic neuropathy Manometry Hyperemia 030204 cardiovascular system & hematology Fingers Diabetic nephropathy Peripheral Arterial Disease 03 medical and health sciences Hyperaemia 0302 clinical medicine Heart Rate Predictive Value of Tests Internal medicine Heart rate medicine Humans Arterial Pressure Diabetic Nephropathies Prospective Studies 030212 general & internal medicine Endothelial dysfunction Aged Heart Failure Ejection fraction business.industry Reproducibility of Results Middle Aged medicine.disease Vasodilation Heart failure Hypertension Cardiology Female Endothelium Vascular medicine.symptom Cardiology and Cardiovascular Medicine business Heart failure with preserved ejection fraction |
| Zdroj: | Vascular Medicine. 22:292-300 |
| ISSN: | 1477-0377 1358-863X |
| DOI: | 10.1177/1358863x17706752 |
| Popis: | Endothelial dysfunction plays a major role in cardiovascular diseases and pulse amplitude tonometry (PAT) offers a non-invasive way to assess endothelial dysfunction. However, data about the reliability of PAT in cardiovascular patient populations are scarce. Thus, we evaluated the test-retest reliability of PAT using the natural logarithmic transformed reactive hyperaemia index (LnRHI). Our cohort consisted of 91 patients (mean age: 65±9.7 years, 32% female), who were divided into four groups: those with heart failure with preserved ejection fraction (HFpEF) ( n=25), heart failure with reduced ejection fraction (HFrEF) ( n=22), diabetic nephropathy ( n=21), and arterial hypertension ( n=23). All subjects underwent two separate PAT measurements at a median interval of 7 days (range 4–14 days). LnRHI derived by PAT showed good reliability in subjects with diabetic nephropathy (intra-class correlation (ICC) = 0.863) and satisfactory reliability in patients with both HFpEF (ICC = 0.557) and HFrEF (ICC = 0.576). However, in subjects with arterial hypertension, reliability was poor (ICC = 0.125). We demonstrated that PAT is a reliable technique to assess endothelial dysfunction in adults with diabetic nephropathy, HFpEF or HFrEF. However, in subjects with arterial hypertension, we did not find sufficient reliability, which can possibly be attributed to variations in heart rate and the respective time of the assessments. Clinical Trial Registration Identifier: NCT02299960. |
| Databáze: | OpenAIRE |
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