| Autor: |
Rafael Selgas, Jesús Egido, María Concepción Izquierdo, Liliana Gonzalez-Espinoza, Alvaro C. Ucero, Alberto Ortiz, Maria Dolores Sanchez-Niño, Olga Ruiz-Andres, Marta Ruiz-Ortega, Ana Belen Sanz, Jonay Poveda |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
International reviews of immunology. 33(1) |
| ISSN: |
1563-5244 |
| Popis: |
Recent advances in cell death biology have uncovered an ever increasing range of cell death forms. Macrophages have a bidirectional relationship with cell death that modulates the immune response. Thus, macrophages engulf apoptotic cells and secrete cytokines that may promote cell death in parenchymal cells. Furthermore, the presence of apoptotic or necrotic dead cells in the microenvironment elicits differential macrophage responses. Apoptotic cells elicit anti-inflammatory responses in macrophages. By contrast macrophages may undergo a proinflammatory form of cell death (pyroptosis) in response to damage-associated molecular patterns (DAMPs) released from necrotic cells and also in response to pathogen-associated molecular patterns (PAMPs). Pyroptosis is a recently identified form of cell death that occurs predominantly in subsets of inflammatory macrophages and is associated to the release of interleukin-1β (IL-1β) and IL-18. Deregulation of these processes may result in disease. Thus, failure of macrophages to engulf apoptotic cells may be a source of autoantigens in autoimmune diseases, excessive macrophage release of proapoptotic factors or sterile pyroptosis may contribute to tissue injury and failure of pathogen-induced pyroptosis may contribute to pathogen survival. Ongoing research is exploring the therapeutic opportunities resulting this new knowledge. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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