The relationship between the CAPRA-S and the time of biochemical recurrence following radical prostatectomy
| Autor: | Süleyman Tağcı, Cüneyt Özden, Yalçın Kızılkan, Samet Şenel, Doruk Demirel, Binhan Kağan Aktaş, Cevdet Serkan Gökkaya, Süleyman Bulut |
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| Rok vydání: | 2021 |
| Předmět: |
Biochemical recurrence
medicine.medical_specialty biology business.industry Prostatectomy medicine.medical_treatment Urology Specialties of internal medicine medicine.disease biology.organism_classification Diseases of the genitourinary system. Urology Prostate cancer RC581-951 Medicine RC870-923 Capra business |
| Zdroj: | Yeni Üroloji Dergisi, Vol 16, Iss 3, Pp 254-261 (2021) |
| ISSN: | 2687-1955 1305-2489 |
| DOI: | 10.33719/yud.2021;16-3-908452 |
| Popis: | Objective: In this study, we aimed to evaluate the relationship between biochemical recurrence time and the “cancer of the prostate risk assessment post-surgery” score (CAPRA-S) after radical prostatectomy (RP). Material and Methods: Retrospective evaluation was made of the records of 328 patients applied with RP for a diagnosis of clinically localized prostate cancer. The patients were separated into groups according to the CAPRA-S score determined according to the preoperative PSA level and pathological characteristics of the RP specimen and the biochemical recurrence time after RP. Results: The mean follow-up period was 76.9±34.5 months. Biochemical recurrence was determined in 23.2% (n:69) of the cases, as early recurrence in 71% (n:49) and late in 29% (n:20). According to the CAPRA-S score, 186 (62.4%) patients were classified as low risk, 66 (22.1%) as moderate risk, and 46 (15%) as high risk. The 3 and 5-year BRFS rates of all the patients were 88.9% and 81.8% respectively. Patients with a low CAPRA-S score were determined to have a statistically significantly higher 3 and 5-year BRFS rate than patients in the moderate and high groups. Early biochemical recurrence after RP was statistically significantly correlated only with lymph node involvement (OR: 2.42, 95% CI: 1.07-5.47, p=0.03). Conclusion: This study showed that the CAPRA-S score, which is effective in predicting the risk of biochemical recurrence after RP, was not effective in predicting the time of biochemical recurrence after RP. Keywords: Biochemical recurrence, CAPRA-S score, prostate cancer, radical prostatectomy |
| Databáze: | OpenAIRE |
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