Low levels of dehydroepiandrosterone sulfate are associated with the risk of developing cardiac autonomic dysfunction in elderly subjects
| Autor: | Carla Cristina de Sordi, Octávio Barbosa Neto, Rosângela Soares Chriguer, Marina de Paiva Lemos, Moacir Marocolo, Elisabete Aparecida Mantovani Rodrigues de Resende, Munique Miranda |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Aging dehydroepiandrosterone sulfate Heart Diseases Endocrinology Diabetes and Metabolism Hemodynamics lcsh:Medicine 030209 endocrinology & metabolism Positive correlation lcsh:Diseases of the endocrine glands. Clinical endocrinology Risk Assessment 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dehydroepiandrosterone sulfate Age groups Heart Rate cardiovascular disease Internal medicine Medicine Heart rate variability Humans Aged lcsh:RC648-665 business.industry Dehydroepiandrosterone Sulfate cardiac autonomic modulation lcsh:R heart rate variability Middle Aged Middle age Young age Endocrinology chemistry Autonomic Nervous System Diseases 030220 oncology & carcinogenesis Female Autonomic modulation business Biomarkers |
| Zdroj: | Archives of Endocrinology and Metabolism v.63 n.1 2019 Arquivos de Endocrinologia e Metabolismo Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM Archives of Endocrinology and Metabolism, Volume: 63, Issue: 1, Pages: 62-69, Published: JAN 2019 Archives of Endocrinology and Metabolism, Vol 63, Iss 1, Pp 62-69 |
| Popis: | Objective: To assess the relationships between serum dehydroepiandrosterone sulfate (DHEA-S) levels and heart rate variability (HRV) among different age groups. Subjects and methods: Forty-five healthy men were divided into 3 groups: young age (YA; 20-39 yrs; n = 15), middle age (MA; 40-59 yrs; n = 15) and old age (OA; ≥ 60 yrs; n = 15). Hemodynamic parameters, linear analyses of HRV and concentrations of cortisol and DHEA-S were measured at rest. Results: The OA group presented a higher resting heart rate (84.3 ± 4.6 bpm) than the YA group (72.0 ± 4.4 bpm; p < 0.05). The YA group showed an attenuated variance of HRV (2235.1 ± 417.9 ms2) compared to the MA (1014.3 ± 265.2 ms2; p < 0.05) and OA (896.3 ± 274.1 ms2; p < 0.05) groups, respectively. The parasympathetic modulation of HRV was lower in both the MA (244.2 ± 58.0 ms2) and OA (172.8 ± 37.9 ms2) groups in comparison with the YA group (996.0 ± 255.4 ms2; p < 0.05), while serum DHEA-S levels were significantly lower in both the MA (91.2 ± 19.6 mg/dL) and OA (54.2 ± 17.7 mg/dL) groups compared to the YA group (240.0 ± 50.8 mg/dL; p < 0.05). A positive correlation between lower serum concentrations of DHEA-S and attenuated variance of HRV (r = 0.47, p = 0.031), as well as lower serum concentrations of DHEA-S and decreased parasympathetic modulation of HRV (r = 0.54, p = 0.010), were found. Conclusion: The present study demonstrated that the decline of plasma DHEA-S is associated with reduced cardiac autonomic modulation during the aging process. |
| Databáze: | OpenAIRE |
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