Development of Immunocompetence: Role of Micronutrients and Microorganisms
| Autor: | Susanna Cunningham-Rundles, B S Rachel Abuav-Nussbaum, Siv Ahrn, Ann M. Dnistrian |
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| Rok vydání: | 2002 |
| Předmět: |
Micronutrient deficiency
medicine.medical_treatment Medicine (miscellaneous) HIV Infections Biology Immune system Bacteriocins Antigen Immunity Immunopathology medicine Humans Micronutrients Immunity Cellular Nutrition and Dietetics Vitamin A Deficiency Infant Newborn Infant Micronutrient Infectious Disease Transmission Vertical Failure to Thrive Cytokine Immunology bacteria Immunocompetence Digestive System |
| Zdroj: | Nutrition Reviews. 60:S68-S72 |
| ISSN: | 1753-4887 0029-6643 |
| Popis: | Normal maturation of immune response at birth is both supported and stimulated by the gastrointestinal microenvironment, which provides both nutrients and antigenic microbial exposure to the developing child. Micronutrients, trace elements, and vitamins are present in the local environment and have important regulatory effects on adaptive immune cell function through effects on type of cytokine response. Congenital HIV infection is critically affected by both nutrient imbalance and alteration in gastrointestinal microflora, which may impair growth and development as well as immune response. Studies described here indicate that micronutrient deficiency is common in congenital HIV exposure even where infection has not occurred and that gastrointestinal recolonization may exert a restorative effect on both immune response and growth in children with HIV infection. |
| Databáze: | OpenAIRE |
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