Expression and Function of Junctional Adhesion Molecule-C in Myelinated Peripheral Nerves

Autor: Beat A. Imhof, Peter J. Coffey, Rime Madani, Alexander Lobrinus, Ralf H. Adams, Dominique Ducrest-Gay, Richard Reynolds, Michel Aurrand-Lions, Dorothée Caille, Sussan Nourshargh, Yiangos Yiangou, Thomas E. Salt, Praveen Anand, Owain W. Howell, Alan S.L. Yu, Paolo Meda, Christoph Scheiermann
Rok vydání: 2007
Předmět:
Membrane Proteins/ metabolism
education
Neural Conduction
Immunoglobulins
Action Potentials
Schwann cell
ddc:616.07
Biology
Nerve Fibers
Myelinated
Cell junction
Article
Mice
Immunolabeling
Myelin
Sural Nerve
Peripheral Nerves/ metabolism/physiology
medicine
Animals
Humans
Peripheral Nerves
Myelin Sheath
Mice
Knockout
Multidisciplinary
Cell adhesion molecule
Sural Nerve/metabolism/physiology
fungi
Cell Adhesion Molecules/ metabolism
Membrane Proteins
Peripheral Nervous System Diseases
Schwann Cells/ metabolism
Nerve Fibers
Myelinated/metabolism/ physiology/ultrastructure
Anatomy
Sciatic Nerve
Intercellular Junctions/metabolism
humanities
Cell biology
Myelin Sheath/metabolism/ physiology/ultrastructure
Intercellular Junctions
medicine.anatomical_structure
nervous system
Neuroglia
Sciatic Nerve/metabolism/physiology/ultrastructure
Schwann Cells
Sciatic nerve
Cell Adhesion Molecules
Immunoglobulins/ metabolism
Peripheral Nervous System Diseases/metabolism/pathology/physiopathology
Junctional Adhesion Molecule C
Zdroj: Science, Vol. 318, No 5855 (2007) pp. 1472-1475
ISSN: 1095-9203
0036-8075
DOI: 10.1126/science.1149276
Popis: JAM-C is an adhesion molecule that is expressed on cells within the vascular compartment and epithelial cells and, to date, has been largely studied in the context of inflammatory events. Using immunolabeling procedures in conjunction with confocal and electron microscopy, we show here that JAM-C is also expressed in peripheral nerves and that this expression is localized to Schwann cells at junctions between adjoining myelin end loops. Sciatic nerves from JAM-C–deficient [having the JAM-C gene knocked out (KO)] mice exhibited loss of integrity of the myelin sheath and defective nerve conduction as indicated by morphological and electrophysiological studies, respectively. In addition, behavioral tests showed motor abnormalities in the KO animals. JAM-C was also expressed in human sural nerves with an expression profile similar to that seen in mice. These results demonstrate that JAM-C is a component of the autotypic junctional attachments of Schwann cells and plays an important role in maintaining the integrity and function of myelinated peripheral nerves.
Databáze: OpenAIRE
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