Anticancer activity of Amauroderma rude
| Autor: | Xiang Min Li, Haoran Li, Mian Hua Cai, Xiangling Yang, Hong Hui Pan, Yi Zhen Xie, Burton B. Yang, Chunwei Jiao, Hua Mei Zhong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Mouse
Fungal Physiology Cancer Treatment Amauroderma rude lcsh:Medicine Apoptosis Mice 0302 clinical medicine Molecular Cell Biology Breast Tumors Agaricales Medicine Chinese Traditional lcsh:Science Mice Inbred BALB C 0303 health sciences Multidisciplinary Cell Death biology Traditional medicine Statistics Obstetrics and Gynecology Animal Models Tumor Burden 3. Good health Oncology Medical Microbiology 030220 oncology & carcinogenesis Medicine Female Research Article Programmed cell death Cell Survival Mice Nude Antineoplastic Agents Breast Neoplasms Mycology Fungus Biostatistics Microbiology Cell Growth 03 medical and health sciences Model Organisms Complementary and Alternative Medicine Cell Line Tumor Breast Cancer medicine Animals Fruiting Bodies Fungal Biology 030304 developmental biology Ganodermataceae lcsh:R Fungi Cancers and Neoplasms Cancer Fungal Polysaccharides biology.organism_classification medicine.disease Xenograft Model Antitumor Assays Fungal Classification Cancer cell Immunology lcsh:Q Mathematics |
| Zdroj: | PLoS ONE, Vol 8, Iss 6, p e66504 (2013) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | More and more medicinal mushrooms have been widely used as a miraculous herb for health promotion, especially by cancer patients. Here we report screening thirteen mushrooms for anti-cancer cell activities in eleven different cell lines. Of the herbal products tested, we found that the extract of Amauroderma rude exerted the highest activity in killing most of these cancer cell lines. Amauroderma rude is a fungus belonging to the Ganodermataceae family. The Amauroderma genus contains approximately 30 species widespread throughout the tropical areas. Since the biological function of Amauroderma rude is unknown, we examined its anti-cancer effect on breast carcinoma cell lines. We compared the anti-cancer activity of Amauroderma rude and Ganoderma lucidum, the most well-known medicinal mushrooms with anti-cancer activity and found that Amauroderma rude had significantly higher activity in killing cancer cells than Ganoderma lucidum. We then examined the effect of Amauroderma rude on breast cancer cells and found that at low concentrations, Amauroderma rude could inhibit cancer cell survival and induce apoptosis. Treated cancer cells also formed fewer and smaller colonies than the untreated cells. When nude mice bearing tumors were injected with Amauroderma rude extract, the tumors grew at a slower rate than the control. Examination of these tumors revealed extensive cell death, decreased proliferation rate as stained by Ki67, and increased apoptosis as stained by TUNEL. Suppression of c-myc expression appeared to be associated with these effects. Taken together, Amauroderma rude represented a powerful medicinal mushroom with anti-cancer activities. |
| Databáze: | OpenAIRE |
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