Dimorphic effect of 17β-oestradiol on pathology and oxidative stress in experimental malaria
| Autor: | Luis Antonio Cervantes-Candelas, Monserrat Sofía López-Padilla, Armando Cervantes-Sandoval, Jesús Aguilar-Castro, Omar Fernández-Rivera, Fidel Orlando Buendía-González, Martha Legorreta-Herrera, Teresita de Jesús Nolasco-Pérez |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Plasmodium berghei Immunology Spleen medicine.disease_cause Parasitemia Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound Antimalarials Mice 0302 clinical medicine parasitic diseases medicine Immunology and Allergy Animals Humans Castration chemistry.chemical_classification Sex Characteristics biology Estradiol Glutathione peroxidase Body Weight Hematology biology.organism_classification Malondialdehyde Malaria Sexual dimorphism Oxidative Stress 030104 developmental biology medicine.anatomical_structure chemistry Models Animal biology.protein Mice Inbred CBA Female Oxidative stress 030215 immunology Hormone |
| Zdroj: | Immunobiology. 225(1) |
| ISSN: | 1878-3279 |
| Popis: | Malaria is the parasitic disease with the highest mortality worldwide; males exhibit higher mortality and more severe symptomatology than females, suggesting the participation of sexual hormones in protection and pathology. We have documented that gonadectomy modifies oxidative stress in Plasmodium berghei ANKA-infected mice in a dimorphic manner. However, gonadectomy decreases all sexual steroids levels, making it difficult to determine the contribution of each hormone to the results. This study aimed to explore the participation of 17β-oestradiol (E2) in oxidative stress in the blood, spleen, liver and brain of P. berghei-infected female and male mice. E2 was administered to intact or gonadectomized (GX) male and female mice to assess their effects on parasitaemia, body weight loss and hypothermia. We also measured the effect of E2 on the specific activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and on malondialdehyde (MDA) levels in the blood, spleen, liver and brain of CBA/Ca male and female mice infected with P. berghei ANKA. We detected the effects of E2 and sexual dimorphism on all tissues and variables analysed. Administration of E2 increased parasitaemia in intact mice. However, reconstitution of GX female mice with E2 decreased parasitaemia. E2 decreased body weight and differentially modulated oxidative stress depending on the sex, infection and tissue analysed. Low antioxidant activity was detected in the brain, suggesting additional protective antioxidant mechanisms in the brain independent of antioxidant enzymes. Our results explained, at least in part, the sexual dimorphism in this experimental model of malaria. |
| Databáze: | OpenAIRE |
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