Restoration of the photoreceptor outer segment and visual outcomes after macular hole closure: spectral-domain optical coherence tomography analysis
| Autor: | Masataka Shimozono, Yasuo Kurimoto, Masayuki Hata, Akio Oishi |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Fovea Centralis Visual acuity Time Factors genetic structures Closure (topology) Visual Acuity Cellular and Molecular Neuroscience Optics Folic Acid Optical coherence tomography Foveal Vitrectomy medicine Humans External limiting membrane Macular hole Aged Retrospective Studies Physics Aged 80 and over medicine.diagnostic_test business.industry Recovery of Function Middle Aged medicine.disease Retinal Perforations Retinal Photoreceptor Cell Outer Segment Photoreceptor outer segment eye diseases Sensory Systems Ophthalmology medicine.anatomical_structure Treatment Outcome Female sense organs Tomography medicine.symptom business Tomography Optical Coherence Follow-Up Studies |
| Zdroj: | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 249(10) |
| ISSN: | 1435-702X |
| Popis: | To evaluate the prognostic value of foveal microstructures as determined using spectral-domain optical coherence tomography (SD-OCT) in eyes with surgically closed macular holes (MHs).Thirty eyes of 30 patients that underwent successful vitrectomy for idiopathic MHs were studied. Best-corrected visual acuity (BCVA) and SD-OCT images of the fovea were examined preoperatively and at 2 weeks, 1, 3, and 6 months postoperatively. The SD-OCT characteristics evaluated included MH diameter, external limiting membrane (ELM) defect diameter, photoreceptor inner/outer segment (IS/OS) junction defect diameter, the presence or absence of subretinal fluid (SRF), central foveal thickness (CFT), and outer foveal thickness (the distance between the ELM and the inner border of the retinal pigment epithelium). The correlations between SD-OCT parameters and BCVA were analyzed.The IS/OS junction defect diameter was most strongly correlated with BCVA at 2 weeks and 1 month postoperatively while outer foveal thickness showed the strongest correlation with BCVA at 3 and 6 months. Outer foveal thickness gradually increased over the follow-up period. Among the pre- and early postoperative quantitative parameters, the only significant predictors of BCVA at 6 months were the IS/OS junction defect diameter and outer foveal thickness at 2 weeks (p = 0.012, p = 0.018, respectively). Disrupted ELM at 2 weeks was also associated with significantly poorer BCVA at 6 months (p 0.001).An increase in outer foveal thickness, indicating photoreceptor outer segment restoration, is an important factor for visual recovery after MH surgery. |
| Databáze: | OpenAIRE |
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