The gonadotropin-releasing hormone system: Perspectives from reproduction to cancer (Review)
| Autor: | Guadalupe Maya-Núñez, Marco Allán Pérez-Solis, Arturo Aguilar-Rojas |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Protein Folding Cancer Research Molecular Sequence Data Breast Neoplasms Biology Bioinformatics medicine.disease_cause Gonadotropic cell Gonadotropin-Releasing Hormone 03 medical and health sciences 0302 clinical medicine Protein Domains Neoplasms medicine Humans Hormone metabolism Amino Acid Sequence Receptor Ovarian Neoplasms Cell growth Reproduction Cell Membrane Prostatic Neoplasms Cell cycle Hormones Endometrial Neoplasms Cell biology 030104 developmental biology Gene Expression Regulation Oncology Pituitary Gland 030220 oncology & carcinogenesis Cancer cell Female Signal transduction Carcinogenesis Receptors LHRH Signal Transduction |
| Zdroj: | International Journal of Oncology. 48:861-868 |
| ISSN: | 1791-2423 1019-6439 |
| Popis: | Recently, an increasing amount of evidence indicates that human gonadotropin-releasing hormone (hGnRH) and its receptor (hGnRHR) are important regulatory components not only to the reproduction process but also in the regulation of some cancer cell functions such as cell proliferation, in both hormone-dependent and -independent types of tumors. The hGnRHR is a naturally misfolded protein that is retained mostly in the endoplasmic reticulum; however, this mechanism can be overcome by treatment with several pharmacoperones, therefore, increasing the amount of receptors in the cell membrane. In addition, several reports indicate that the expression level of hGnRHR in tumor cells is even lower than in pituitary or gonadotrope cells. The signal transduction pathways activated by hGnRH in both gonadotrope and different cancer cell types are described in the present review. We also discuss how the rescue of misfolded receptors in tumor cells could be a promising strategy for cancer therapy. |
| Databáze: | OpenAIRE |
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