Echinochrome A Protects against Ultraviolet B-induced Photoaging by Lowering Collagen Degradation and Inflammatory Cell Infiltration in Hairless Mice
| Autor: | Sergey A. Fedoreyev, Hyeong Rok Yun, Hyoung Kyu Kim, Nammi Park, Bomin Seol, Valentin A. Stonik, Natalia P. Mishchenko, Elena A. Vasileva, Jung Eun Seol, Sang Woo Ahn, Jin Han |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Aquatic Organisms photoaging QH301-705.5 Ultraviolet Rays medicine.medical_treatment Photoaging Intraperitoneal injection Pharmaceutical Science Tryptase medicine.disease_cause Protective Agents Article Mice Internal medicine Drug Discovery medicine Stratum corneum Animals Mast Cells Biology (General) Pharmacology Toxicology and Pharmaceutics (miscellaneous) Transepidermal water loss echinochrome A Mice Hairless biology integumentary system Chemistry Chymase dermal collagen degeneration medicine.disease Water Loss Insensible Hairless Skin Aging Disease Models Animal Endocrinology medicine.anatomical_structure mast cell infiltration biology.protein hairless mice Collagen Oxidative stress Naphthoquinones |
| Zdroj: | Marine Drugs Marine Drugs, Vol 19, Iss 550, p 550 (2021) Volume 19 Issue 10 |
| ISSN: | 1660-3397 |
| Popis: | Echinochrome A (Ech A, 7-ethyl-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone) has been known to exhibit anti-oxidative and anti-inflammatory effects. However, no study has been carried out on the efficacy of Ech A against skin photoaging this process is largely mediated by oxidative stress. Six-week-old male SKH-1 hairless mice (n = 36) were divided into five groups. Except for a group that were not treated (n = 4), all mice underwent ultraviolet-B (UVB) exposure for 8 weeks while applying phosphate-buffered saline or Ech A through intraperitoneal injection. UVB impaired skin barrier function, showing increased transepidermal water loss and decreased stratum corneum hydration. UVB induced dermal collagen degeneration and mast cell infiltration. Ech A injection was found to significantly lower transepidermal water loss while attenuating tissue inflammatory changes and collagen degeneration compared to the control. Furthermore, Ech A was found to decrease the relative expression of matrix metalloproteinase, tryptase, and chymase. Taken together, these results suggest that Ech A protects against UVB-induced photoaging in both functional and histologic aspects, causing a lowering of collagen degradation and inflammatory cell infiltration. |
| Databáze: | OpenAIRE |
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