Impact of COMT val158met on tDCS-induced cognitive enhancement in older adults
| Autor: | Agnes Flöel, Nadine Külzow, Dayana Hayek, Ulrike Grittner, Sophie Lehnerer, Kristin Prehn, Dan Rujescu, Alice Schneider, A. Veronica Witte, Marcus Meinzer, Daria Antonenko |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Apolipoprotein E Male medicine.medical_specialty Aging Plasticity medicine.medical_treatment genetics [Catechol O-Methyltransferase] Transcranial Direct Current Stimulation Catechol O-Methyltransferase 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Cognition physiology [Cerebral Cortex] Neurotrophic factors Internal medicine medicine Genetics Humans Effects of sleep deprivation on cognitive performance ddc:610 030304 developmental biology Aged Aged 80 and over Cerebral Cortex 0303 health sciences Polymorphism Genetic Transcranial direct-current stimulation business.industry physiology [Cognition] Middle Aged Individual variability Cognitive functions Clinical trial Behavioral response Brain stimulation FOS: Biological sciences Female Transcranial direct current stimulation business 030217 neurology & neurosurgery 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit |
| Zdroj: | Behavioural brain research 401, 113081-(2021). doi:10.1016/j.bbr.2020.113081 |
| DOI: | 10.1016/j.bbr.2020.113081 |
| Popis: | Background Previous studies suggest that genetic polymorphisms and aging modulate inter-individual variability in brain stimulation-induced plasticity. However, the relationship between genetic polymorphisms and behavioral modulation through transcranial direct current stimulation (tDCS) in older adults remains poorly understood. Objective Link individual tDCS responsiveness, operationalized as performance difference between tDCS and sham condition, to common genetic polymorphisms in healthy older adults. Methods 106 healthy older participants from five tDCS-studies were re-invited to donate blood for genotyping of apoliproprotein E (APOE: e4 carriers and e4 non-carriers), catechol-O-methyltransferase (COMT: val/val, val/met, met/met), brain-derived neurotrophic factor (BDNF: val/val, val/met, met/met) and KIdney/BRAin encoding gene (KIBRA: C/C, C/T, T/T). Studies had assessed cognitive performance during tDCS and sham in cross-over designs. We now asked whether the tDCS responsiveness was related to the four genotypes using a linear regression models. Results We found that tDCS responsiveness was significantly associated with COMT polymorphism; i.e., COMT val carriers (compared to met/met) showed higher tDCS responsiveness. No other significant associations emerged. Conclusion Using data from five brain stimulation studies conducted in our group, we showed that only individual variation of COMT genotypes modulated behavioral response to tDCS. These findings contribute to the understanding of inherent factors that explain inter-individual variability in functional tDCS effects in older adults, and might help to better stratify participants for future clinical trials. |
| Databáze: | OpenAIRE |
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