Prospective study of hair recovery after (neo)adjuvant chemotherapy with scalp cooling in Japanese breast cancer patients
| Autor: | Sachiko Kiyoto, Shozo Ohsumi, Kenjiro Aogi, Mina Takahashi, Sachie Shimizu, Seiki Takashima, Miyuki Doi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Scalp cooling Adjuvant chemotherapy medicine.medical_treatment Breast Neoplasms Asian women Group B 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Breast cancer Japan Hypothermia Induced Antineoplastic Combined Chemotherapy Protocols medicine Chemotherapy Humans Prospective Studies Prospective cohort study Neo adjuvant chemotherapy Hair recovery Scalp integumentary system business.industry Alopecia medicine.disease Surgery Hair loss Oncology Chemotherapy Adjuvant 030220 oncology & carcinogenesis Original Article Female business |
| Zdroj: | Supportive Care in Cancer |
| ISSN: | 1433-7339 0941-4355 |
| Popis: | Purpose Scalp cooling during chemotherapy infusion to mitigate alopecia for breast cancer patients is becoming widespread; however, studies regarding hair recovery after chemotherapy with scalp cooling are limited. We conducted a prospective study of hair recovery after chemotherapy with scalp cooling. Patients and methods One hundred and seventeen Japanese female breast cancer patients who completed planned (neo)adjuvant chemotherapy using the Paxman Scalp Cooling System for alopecia prevention were evaluated for alopecia prevention in our prospective study. We evaluated their hair recovery 1, 4, 7, 10, and 13 months after chemotherapy. Primary outcomes were grades of alopecia judged by two investigators (objective grades) and patients’ answers to the questionnaire regarding the use of a wig or hat (subjective grades). Results Of 117 patients, 75 completed scalp cooling during the planned chemotherapy cycles (Group A), but 42 discontinued it mostly after the first cycle (Group B). Objective and subjective grades were significantly better in Group A than in Group B throughout 1 year, and at 4 and 7 months after chemotherapy. When we restricted patients to those with objective Grade 3 (hair loss of > 50%) at 1 month, Group A exhibited slightly faster hair recovery based on the objective grades than Group B. There was less persistent alopecia in Group A than in Group B. Conclusions Scalp cooling during chemotherapy infusion for Japanese breast cancer patients increased the rate of hair recovery and had preventive effects against persistent alopecia. |
| Databáze: | OpenAIRE |
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