Association between Cell Membrane Potential and Breast Cancer
| Autor: | Andrew A. Marino, Michael A. Schwalke, Ilko G. Iliev, Carol A. Flanagan, Kevin C. Marler, Enrique Gonzalez |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Breast biopsy Pathology medicine.medical_specialty Potassium Channels Mammary gland Breast Neoplasms Biology medicine.disease_cause Membrane Potentials Breast cancer medicine Humans Breast skin and connective tissue diseases Aged Membrane potential medicine.diagnostic_test Carcinoma Ductal Breast Cell Membrane Depolarization General Medicine Middle Aged medicine.disease medicine.anatomical_structure Adenocarcinoma Female Breast disease Carcinogenesis |
| Zdroj: | Tumor Biology. 15:82-89 |
| ISSN: | 1423-0380 1010-4283 |
| Popis: | Cell membrane potentials were measured in breast tissue and in breast epithelial cells to explore the relation between cell membrane potentials, oncogenesis and electrical potentials previously measured on the surface of the breast. The mean membrane potential in breast biopsy tissue from 9 women with infiltrating ductal carcinoma was significantly depolarized, compared with values measured in tissue from 8 women with benign breast disease. Depolarization was also observed in transformed breast epithelial cells, compared with normal breast cells; the transformed cells were particularly sensitive to the action of K+ channel blockers. The results were consistent with previous observations of electropositivity of skin sites over malignant tumors of the breast. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|