Urinary leukotrienes in patients with nasal polyposis
| Autor: | Michel Royer, María Antonieta Guzmán, Gonzalo Nazar, Juan-Pablo Gormaz |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Urinary system Gastroenterology Excretion chemistry.chemical_compound Nasal Polyps Disease severity Internal medicine medicine Humans In patient Prospective Studies Prospective cohort study Aged Leukotriene E4 Aspirin Leukotriene business.industry Middle Aged Otorhinolaryngology chemistry Immunology Female Surgery business medicine.drug |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 138:633-636 |
| ISSN: | 1097-6817 0194-5998 |
| DOI: | 10.1016/j.otohns.2008.02.001 |
| Popis: | Objectives To compare urinary leukotriene E4 (ULT) level in patients with nasal polyposis (NP) with and without aspirin intolerance and allergic rhinitis (AR), and correlate it with disease severity. Study Design and Setting Prospective study from November 2005 to November 2006. Patients with NP (n = 30) and AR (n = 35) were included. The concentration of ULT was measured in both groups. Oral provocation test with aspirin was performed to patients with NP. ULT level between both groups was compared and correlated with NP disease severity. Results ULT concentration was elevated on NP and AR. The patients with NP and aspirin intolerance (n = 4) presented higher levels of ULT compared to aspirin-tolerant patients. Leukotriene concentration was not correlated with NP severity. Conclusions Patients with NP and aspirin intolerance have increased ULT excretion; thus their measurement can be used as an indicator of arachidonic acid metabolism alteration. |
| Databáze: | OpenAIRE |
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