Relationship between bladder cancer incidence, Schistosoma haematobium infection, and geographical region in Zimbabwe
| Autor: | Mary T. Bassett, James E. Thomas, Lynette B. Sigola, Paul Taylor |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Zimbabwe medicine.medical_specialty Pathology Adolescent Helminthiasis Schistosomiasis urologic and male genital diseases Gastroenterology Schistosomiasis haematobia Internal medicine parasitic diseases medicine Carcinoma Animals Humans Child Aged Demography Retrospective Studies Schistosoma haematobium Carcinoma Transitional Cell Bladder cancer Urinary bladder biology Incidence (epidemiology) Age Factors Public Health Environmental and Occupational Health Retrospective cohort study General Medicine Middle Aged biology.organism_classification medicine.disease Infectious Diseases medicine.anatomical_structure Urinary Bladder Neoplasms Carcinoma Squamous Cell Female Parasitology |
| Zdroj: | Transactions of the Royal Society of Tropical Medicine and Hygiene. 84:551-553 |
| ISSN: | 0035-9203 |
| DOI: | 10.1016/0035-9203(90)90036-e |
| Popis: | Bladder cancer is common in Zimbabwe, possibly due to the high prevalence of Schistosoma haematobium infection in some areas. We undertook a correlational study based on retrospective medical record review to see whether the number of bladder cancers could be related to geographical region and prevalence of S. haematobium infection. We also determined patient demographic characteristics and tumour histology. Of 483 patients identified (1984-1987), 69% with available histology had squamous cell carcinomas. The remainder had transitional cell carcinomas. Patients with squamous cell carcinoma were younger than patients with transitional cell carcinomas (50% vs 20% under 50 years old, P less than 0.05) and had a sex ratio of one. There was a positive geographical relationship between S. haematobium prevalence and the incidence of squamous cell carcinoma of the bladder: provinces with high prevalence of S. haematobium had more bladder cancer cases with a predominance of squamous cell carcinoma (r = 0.87, P less than 0.01). These data support a casual relationship between S. haematobium infection and squamous cell carcinoma of the bladder. |
| Databáze: | OpenAIRE |
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