Mathematical Modelling of the Effects of Plasma Treatment on the Diffusivity of Biofilm
| Autor: | Ronald Fournier, Halim Ayan, Tripti Thapa Gupta, Surya B. Karki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
non-thermal plasma 030106 microbiology Plasma treatment Nonthermal plasma medicine.disease_cause Thermal diffusivity 01 natural sciences lcsh:Technology biofilm CHX lcsh:Chemistry 03 medical and health sciences Extracellular polymeric substance 0103 physical sciences medicine General Materials Science mathematical modelling Instrumentation lcsh:QH301-705.5 010302 applied physics Fluid Flow and Transfer Processes Chemistry Pseudomonas aeruginosa lcsh:T Process Chemistry and Technology Chlorhexidine diffusion General Engineering Biofilm biochemical phenomena metabolism and nutrition Antimicrobial lcsh:QC1-999 Computer Science Applications Chemical engineering lcsh:Biology (General) lcsh:QD1-999 lcsh:TA1-2040 lcsh:Engineering (General). Civil engineering (General) lcsh:Physics medicine.drug |
| Zdroj: | Applied Sciences, Vol 8, Iss 10, p 1729 (2018) Applied Sciences Volume 8 Issue 10 |
| ISSN: | 2076-3417 |
| Popis: | Biofilm formation on implanted medical devices is the reason for most of the nosocomial infections in clinical settings. Biofilms are more resistant to antimicrobials than their planktonic cells mainly because of the presence of the matrix of extracellular polymeric substances (EPSs), which acts as a physical barrier that limits the transport of antimicrobials inside the biofilm. A combinatorial antimicrobial approach of a non-thermal plasma and chlorhexidine (CHX) digluconate can be used to sterilize those surfaces contaminated with biofilm. However, the reason behind achieving this combinatorial decontamination is not known. Thus, in this study, we developed a mathematical model to explain the reason behind sterilization with the combinatorial treatment approach. It was found that the application of plasma prior to treatment with CHX is disrupting the biofilm and making it very porous. This is allowing CHX to penetrate deeper inside the porous biofilm, which is then effective at sterilizing the biofilm. |
| Databáze: | OpenAIRE |
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