Dynamic Molecular Evolution of Mammalian Homeobox Genes: Duplication, Loss, Divergence and Gene Conversion Sculpt PRD Class Repertoires
| Autor: | Peter W. H. Holland, Thomas D. Lewin, Amy H. Royall |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Genome evolution Gene Conversion Homeodomain Biology 010603 evolutionary biology 01 natural sciences Genome Evolution Molecular 03 medical and health sciences Molecular evolution Gene Duplication Gene duplication Genetics Animals Etchbox Gene conversion Tandem duplication Molecular Biology Gene Phylogeny Ecology Evolution Behavior and Systematics 030304 developmental biology Mammals 0303 health sciences Genes Homeobox Positive selection Evolutionary biology Homeobox Original Article Rabbits Tandem exon duplication |
| Zdroj: | Journal of Molecular Evolution |
| ISSN: | 1432-1432 0022-2844 |
| Popis: | The majority of homeobox genes are highly conserved across animals, but the eutherian-specific ETCHbox genes, embryonically expressed and highly divergent duplicates of CRX, are a notable exception. Here we compare the ETCHbox genes of 34 mammalian species, uncovering dynamic patterns of gene loss and tandem duplication, including the presence of a large tandem array of LEUTX loci in the genome of the European rabbit (Oryctolagus cuniculus). Despite extensive gene gain and loss, all sampled species possess at least two ETCHbox genes, suggesting their collective role is indispensable. We find evidence for positive selection and show that TPRX1 and TPRX2 have been the subject of repeated gene conversion across the Boreoeutheria, homogenising their sequences and preventing divergence, especially in the homeobox region. Together, these results are consistent with a model where mammalian ETCHbox genes are dynamic in evolution due to functional overlap, yet have collective indispensable roles. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |