Development of a protocol to assess within-subject, regional white matter hyperintensity changes in aging and dementia
| Autor: | Charles D. Smith, Larry B. Goldstein, Erin L. Abner, David K. Powell, Justin M. Barber, Ahmed A. Bahrani, Anders H. Andersen, Donna M. Wilcock, Zachary Winder, Linda J. Van Eldik, Gregory A. Jicha, Brandon D. Ramey, Brian T. Gold, Omar M. Al-Janabi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Aging Fluid-attenuated inversion recovery Article Correlation 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation medicine Dementia Humans Cognitive Dysfunction Cognitive decline Protocol (science) business.industry General Neuroscience medicine.disease Magnetic Resonance Imaging White Matter Hyperintensity Regression 030104 developmental biology White matter hyperintensity business 030217 neurology & neurosurgery |
| Zdroj: | J Neurosci Methods |
| ISSN: | 1872-678X |
| Popis: | BACKGROUND: White matter hyperintensities (WMH), associated with both dementia risk and progression, can individually progress, remain stable, or even regress influencing cognitive decline related to specific cerebrovascular-risks. This study details the development and validation of a registration protocol to assess regional, within-subject, longitudinal WMH changes (ΔWMH) that is currently lacking in the field. NEW METHOD: 3D-FLAIR images (baseline and one-year-visit) were used for protocol development and validation. The method was validated by assessing the correlation between forward and reverse longitudinal registration, and between summated regional progression-regression volumes and Global ΔWMH. The clinical relevance of growth-regression ΔWMH were explored in relation to an executive function test. RESULTS: MRI scans for 79 participants (73.5±8.8 years) were used in this study. Global ΔWMH vs. summated regional progression-regression volumes were highly associated (r 2 =0.90; p-value |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect