Evaluation of ototoxicity in children treated for retinoblastoma: preliminary results of a systematic audiological evaluation
| Autor: | Célia Beatriz Gianotti Antoneli, Paulo Eduardo Ribeiro dos Santos Novaes, Christiane Schultz, Patricia Helena Pecora Liberman, Maria Valéria Schmidt Goffi-Gomez, Martha Motoro Chojniak |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Risk Cancer Research medicine.medical_specialty Hearing loss Otoacoustic Emissions Spontaneous Antineoplastic Agents Audiology Audiological evaluation Audiometry Ototoxicity Multidisciplinary approach otorhinolaryngologic diseases medicine Humans Child Ear Diseases Hearing Loss business.industry Retinoblastoma General Medicine medicine.disease eye diseases Acoustic Impedance Tests Oncology Female Cisplatin medicine.symptom business |
| Zdroj: | Clinical and Translational Oncology. 13:348-352 |
| ISSN: | 1699-3055 1699-048X |
| DOI: | 10.1007/s12094-011-0665-2 |
| Popis: | The objective of this study was to identify the ocurrence of hearing loss in children treated for retinoblastoma using a multidisciplinary approach.Thirty-two children were evaluated pre- and post-treatment. Eleven children were treated exclusively with enucleation, fifteen with carboplatin and six with cisplatin. Otoacoustic emissions were performed with the ILO 88, before and after the treatment.In our study we found 5 children (24%) with hearing loss among the 21 evaluated. However in the group of children treated with carboplatin (N=15), 1 case (6.6%) presented hearing loss, while among those treated with cisplatin (N=6) we found 4 cases (66.6%) with hearing loss (p=0.0114).We concluded that patients who are treated with cisplatin are at risk for developing hearing loss. |
| Databáze: | OpenAIRE |
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