On the cutting edge of glioblastoma surgery

Autor: Frederik Barkhof, Wimar A. van den Brink, Albert J S Idema, Philip C. De Witt Hamer, Marjolein Visser, Hilko Ardon, Mitchel S. Berger, Domenique M J Müller, Pierre A. Robe, Seunggu J. Han, Michiel Wagemakers, Tommaso Sciortino, Aeilko H. Zwinderman, Alfred Kloet, Marnix G. Witte, Marco Conti Nibali, Shawn L. Hervey-Jumper, W. Peter Vandertop, Georg Widhalm, Roelant S Eijgelaar, Julia Furtner, Lorenzo Bello, Marco Rossi, Wim Bouwknegt, Jan C. de Munck, Barbara Kiesel, Emmanuel Mandonnet
Přispěvatelé: Neurosurgery, Amsterdam Neuroscience - Neurovascular Disorders, Amsterdam Neuroscience - Systems & Network Neuroscience, CCA - Cancer Treatment and Quality of Life, Epidemiology and Data Science, APH - Methodology, Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Neuroinfection & -inflammation, CCA - Cancer Treatment and quality of life
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Müller, D M J, Robe, P A, Ardon, H, Barkhof, F, Bello, L, Berger, M S, Bouwknegt, W, van den Brink, W A, Conti Nibali, M, Eijgelaar, R S, Furtner, J, Han, S J, Hervey-Jumper, S L, Idema, A J S, Kiesel, B, Kloet, A, Mandonnet, E, de Munck, J C, Rossi, M, Sciortino, T, Vandertop, W P, Visser, M, Wagemakers, M, Widhalm, G, Witte, M G, Zwinderman, A H & de Witt Hamer, P C 2022, ' On the cutting edge of glioblastoma surgery : where neurosurgeons agree and disagree on surgical decisions ', Journal of Neurosurgery, vol. 136, no. 1, pp. 45-55 . https://doi.org/10.3171/2020.11.JNS202897
Journal of neurosurgery, 136(1), 45-55. American Association of Neurological Surgeons
Journal of Neurosurgery, 136(1), 45-55. American Association of Neurological Surgeons
Journal of Neurosurgery, 136(1), 45-55. AMER ASSOC NEUROLOGICAL SURGEONS
ISSN: 0022-3085
Popis: OBJECTIVE The aim of glioblastoma surgery is to maximize the extent of resection while preserving functional integrity. Standards are lacking for surgical decision-making, and previous studies indicate treatment variations. These shortcomings reflect the need to evaluate larger populations from different care teams. In this study, the authors used probability maps to quantify and compare surgical decision-making throughout the brain by 12 neurosurgical teams for patients with glioblastoma. METHODS The study included all adult patients who underwent first-time glioblastoma surgery in 2012–2013 and were treated by 1 of the 12 participating neurosurgical teams. Voxel-wise probability maps of tumor location, biopsy, and resection were constructed for each team to identify and compare patient treatment variations. Brain regions with different biopsy and resection results between teams were identified and analyzed for patient functional outcome and survival. RESULTS The study cohort consisted of 1087 patients, of whom 363 underwent a biopsy and 724 a resection. Biopsy and resection decisions were generally comparable between teams, providing benchmarks for probability maps of resections and biopsies for glioblastoma. Differences in biopsy rates were identified for the right superior frontal gyrus and indicated variation in biopsy decisions. Differences in resection rates were identified for the left superior parietal lobule, indicating variations in resection decisions. CONCLUSIONS Probability maps of glioblastoma surgery enabled capture of clinical practice decisions and indicated that teams generally agreed on which region to biopsy or to resect. However, treatment variations reflecting clinical dilemmas were observed and pinpointed by using the probability maps, which could therefore be useful for quality-of-care discussions between surgical teams for patients with glioblastoma.
Databáze: OpenAIRE
Externí odkaz: