Cannabinoid Transmission in the Basolateral Amygdala Modulates Fear Memory Formation via Functional Inputs to the Prelimbic Cortex

Autor: Nicole M. Lauzon, Melanie Bechard, Ning Chi, Steven R. Laviolette, Huibing Tan, Stephanie F. Bishop
Rok vydání: 2011
Předmět:
Male
Cannabinoid receptor
Morpholines
medicine.medical_treatment
Infralimbic cortex
Action Potentials
Prefrontal Cortex
Arachidonic Acids
Naphthalenes
Functional Laterality
Rats
Sprague-Dawley
Piperidines
Receptor
Cannabinoid
CB1
Memory
medicine
Animals
Premovement neuronal activity
Prefrontal cortex
Neurons
Fear processing in the brain
Afferent Pathways
Analysis of Variance
Electroshock
Dose-Response Relationship
Drug
Cannabinoids
musculoskeletal
neural
and ocular physiology
General Neuroscience
Neural Inhibition
Long-term potentiation
Fear
Articles
Amygdala
Calcium Channel Blockers
Benzoxazines
Rats
Smell
medicine.anatomical_structure
nervous system
Pyrazoles
lipids (amino acids
peptides
and proteins)
Cannabinoid
Psychology
Neuroscience
psychological phenomena and processes
Basolateral amygdala
Zdroj: The Journal of Neuroscience. 31:5300-5312
ISSN: 1529-2401
0270-6474
Popis: The cannabinoid CB1 receptor system is critically involved in the control of associative fear memory formation within the amygdala–prefrontal cortical pathway. The CB1 receptor is found in high concentrations in brain structures that are critical for emotional processing, including the basolateral amygdala (BLA) and the prelimbic division (PLC) of the medial prefrontal cortex (mPFC). However, the precise role of CB1 receptor transmission within the BLA during the processing of fear memory is not fully understood. We examined the potential role of BLA CB1 receptor transmission during an olfactory fear-conditioning procedure in rats by pharmacologically modulating CB1 cannabinoid transmission directly within the BLA. We report that blockade of BLA CB1 receptor transmission prevents the acquisition of associative fear memory, while having no effect on the recall or consolidation of these memories. In contrast, intra-BLA activation of CB1 receptor transmission or blockade of endocannabinoid reuptake strongly potentiated the emotional salience of normally subthreshold fear-conditioning stimuli. In addition, pharmacological inactivation of the mPFC before intra-BLA CB1 activation blocked CB1-receptor-mediated potentiation of fear memory formation.In vivosingle-unit electrophysiological recordings within the PLC revealed that modulation of BLA CB1 receptor transmission strongly influences neuronal activity within subpopulations of PLC neurons, with blockade of intra-BLA CB1 receptor transmission inhibiting spontaneous PLC neuronal activity and activation of CB1 receptors producing robust activation, in terms of neuronal firing frequency and bursting activity. Thus, cannabinoid transmission within the BLA strongly modulates the processing of associative fear memory via functional interactions with PLC neuronal populations.
Databáze: OpenAIRE
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