Five genomic regions have a major impact on fat composition in Iberian pigs
| Autor: | Elena González, M. J. García-Santana, Ramona N. Pena, Roger Ros-Freixedes, J. L. Noguera, J.F. Tejeda, Noelia Ibáñez-Escriche |
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| Přispěvatelé: | Producció Animal, Genètica i Millora Animal |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Meat Swine biology.animal_breed lcsh:Medicine Single-nucleotide polymorphism PRODUCCION ANIMAL Porcs ibèrics Article Fatty Acids Monounsaturated 03 medical and health sciences 0302 clinical medicine Genetic variation Animals Food science Obesity lcsh:Science Unsaturated fatty acid Adiposity Iberian pig ACACA Multidisciplinary Adipogenesis Genome biology lcsh:R Fatty Acids Carn de porc Genomics 030104 developmental biology Phenotype Fatty Acids Unsaturated lcsh:Q Composition (visual arts) Intramuscular fat 030217 neurology & neurosurgery SNP array |
| Zdroj: | Scientific Reports RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname IRTA Pubpro. Open Digital Archive Institut de Recerca i Tecnologia Agroalimentàries (IRTA) Recercat. Dipósit de la Recerca de Catalunya Repositorio Abierto de la UdL Universitad de Lleida Pena, R, Noguera, J L, García-Santana, MJ, González, E, Tejeda, JF, Ros Freixedes, R & Ibanez Escriche, N 2019, ' Five genomic regions have a major impact on fat composition in Iberian pigs ', Scientific Reports, vol. 9, 2031 . https://doi.org/10.1038/s41598-019-38622-7 Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019) |
| DOI: | 10.1038/s41598-019-38622-7 |
| Popis: | [EN] The adipogenic nature of the Iberian pig defines many quality attributes of its fresh meat and dry-cured products. The distinct varieties of Iberian pig exhibit great variability in the genetic parameters for fat deposition and composition in muscle. The aim of this work is to identify common and distinct genomic regions related to fatty acid composition in Retinto, Torbiscal, and Entrepelado Iberian varieties and their reciprocal crosses through a diallelic experiment. In this study, we performed GWAS using a high density SNP array on 382 pigs with the multimarker regression Bayes B method implemented in GenSel. A number of genomic regions showed strong associations with the percentage of saturated and unsaturated fatty acid in intramuscular fat. In particular, five regions with Bayes Factor >100 (SSC2 and SSC7) or >50 (SSC2 and SSC12) explained an important fraction of the genetic variance for miristic, palmitoleic, monounsaturated (>14%), oleic (>10%) and polyunsaturated (>5%) fatty acids. Six genes (RXRB, PSMB8, CHGA, ACACA, PLIN4, PLIN5) located in these regions have been investigated in relation to intramuscular composition variability in Iberian pigs, with two SNPs at the RXRB gene giving the most consistent results on oleic and monounsaturated fatty acid content. The authors would like to acknowledge the help of Inga Food S.A. and their support staff in setting up the experiment (E. Magallon, M. Ramos, L. Munoz, and P. Diaz) and Dr L. Varona from University of Zaragoza for discussion. This study was funded by the INIA grant RTA 2012-0054-C02-01 and the Centre for the Development of Industrial Technology agreement IDI-20140447. |
| Databáze: | OpenAIRE |
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