The distributions of hematologic and biochemical values in healthy high-school adolescents in Japan

Autor: Masaaki Mori, Yasunori Sato, Tatsuhiko Azegami, Nobuko Yamada-Goto, Tomoyasu Nishimura, Ayano Murai-Takeda
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
030213 general clinical medicine
Percentile
Epidemiology
Physiology
Disease
030204 cardiovascular system & hematology
Adolescents
Biochemistry
Pediatrics
Geographical Locations
Disease susceptibility
chemistry.chemical_compound
Families
0302 clinical medicine
Japan
Reference Values
Medicine and Health Sciences
Medicine
Public and Occupational Health
Children
education.field_of_study
Multidisciplinary
Hematologic Tests
Schools
Child Health
Hematology
Lipids
Chemistry
Cholesterol
Creatinine
Physical Sciences
Female
Research Article
Asia
Adolescent
Science
Population
03 medical and health sciences
Humans
education
business.industry
Serum uric acid
Cholesterol
HDL
Chemical Compounds
Biology and Life Sciences
Reference intervals
Uric Acid
chemistry
Age Groups
Medical Risk Factors
People and Places
Uric acid
Population Groupings
business
Acids
Biomarkers
Blood Chemical Analysis
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 11, p e0242272 (2020)
ISSN: 1932-6203
Popis: Laboratory tests of adolescents are often interpreted by using reference intervals derived from adults, even though these populations differ in their physical and physiologic characteristics and disease susceptibility. Therefore, to examine the distribution of laboratory values specific for adolescents, we analyzed hematologic and biochemical measurements obtained from 12,023 healthy Japanese adolescents (ages 15 through 18 years; male, 9165; female, 2858) during 2009 through 2018. Distributions were shown as medians with 95% (2.5th and 97.5th percentiles) of values and were compared with those from previous studies that examined similar Asian populations. There were some differences between hematologic parameters, serum creatinine and uric acid concentration, and lipid levels of Japanese adults and adolescents. In comparison with other Asian populations, the distributions of serum uric acid and high-density–lipoprotein cholesterol in the present study were slightly higher than those in the other studies. Although further research is need, the distributions of hematologic and biochemical tests in adolescents may have the potential to facilitate the early identification and management of disease in this population.
Databáze: OpenAIRE
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