Different Profile of Efficacy of Thiopurines in Ulcerative Colitis and Crohn's Disease
| Autor: | Giovanni Domenico De Palma, Olga Maria Nardone, Anna Testa, Dario Musto, M. Diaferia, Fabiana Castiglione, Antonio Rispo, Francesco Maione, Sara Donetto, Nicola Caporaso |
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| Přispěvatelé: | Rispo, Antonio, Testa, Anna, De Palma, Giovanni Domenico, Donetto, Sara, Diaferia, Maria, Musto, Dario, Nardone, Olga, Maione, Francesco, Caporaso, Nicola, Castiglione, Fabiana |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Antimetabolites Antineoplastic Adolescent IBD Longitudinal Studie Gastroenterology Inflammatory bowel disease ulcerative coliti mucosal healing Young Adult Crohn Disease Internal medicine thiopurine medicine Immunology and Allergy Humans Longitudinal Studies Prospective Studies Colitis Young adult Intestinal Mucosa Prospective cohort study Aged Crohn's disease Thiopurine methyltransferase biology business.industry Mercaptopurine Remission Induction Endoscopy Odds ratio Middle Aged medicine.disease Ulcerative colitis Prospective Studie biology.protein Colitis Ulcerative Female business Human |
| Zdroj: | Inflammatory bowel diseases. 21(11) |
| ISSN: | 1536-4844 |
| Popis: | BACKGROUND Thiopurines are effective drugs in treating ulcerative colitis (UC) and Crohn's disease (CD) even if studies that specifically investigate these drugs' profile of efficacy in UC compared with CD are scarce. Our aim was to compare the profile of efficacy of thiopurines in patients with UC and CD. METHODS We perfomed a longitudinal observational study evaluating steroid-free clinical remission (CR) and mucosal healing (MH) in all patients with UC and CD who would complete 2 years of maintenance treatment with thiopurines. In patients with UC, CR and MH were assessed before starting treatment and 2 years later using the Mayo score (CR = Mayo score |
| Databáze: | OpenAIRE |
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