Flavonoid Constituents of Chorizanthe diffusa with Potential Cancer Chemopreventive Activity
| Autor: | Lisa A. Shamon, Rajendra G. Mehta, Norman R. Farnsworth, Chung Hs, A. D. Kinghorn, Sang Kook Lee, van Breemen Rb, Leng Chee Chang, John M. Pezzuto |
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| Rok vydání: | 1998 |
| Předmět: |
Magnetic Resonance Spectroscopy
Antioxidant DPPH medicine.medical_treatment Flavonoid HL-60 Cells Pharmacognosy Biology Mass Spectrometry Mice chemistry.chemical_compound medicine Animals Anticarcinogenic Agents Humans Anticarcinogen Flavonoids chemistry.chemical_classification Mice Inbred BALB C Traditional medicine Biological activity General Chemistry Plants chemistry Biochemistry General Agricultural and Biological Sciences Quercetin Antimutagen |
| Zdroj: | Journal of Agricultural and Food Chemistry. 47:36-41 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/jf980784o |
| Popis: | An ethyl acetate-soluble extract of Chorizanthe diffusa was found to exhibit significant antioxidant activity, as judged by scavenging stable 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals and inhibition of 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced free radical formation with cultured HL-60 cells. Bioassay-directed fractionation of this extract using the DPPH antioxidant assay as a monitor led to the isolation of five structurally related flavonoids (1−5), including the novel compound 5,8,3‘,4‘,5‘-pentahydroxy-3,7-dimethoxyflavone (1). Isolates 1−5 demonstrated varying degrees of antioxidant or antimutagenic activity. Two of the compounds, 5,7,3‘,4‘-tetrahydroxy-3-methoxyflavone (2) and quercetin (4), were subsequently found to inhibit carcinogen-induced preneoplastic lesions in a mouse mammary organ culture model. Inhibitory activity of this type is known to correlate with cancer chemopreventive effects in full-term models of tumorigenesis. Keywords: Chorizanthe diffusa; Polygonaceae; flavon... |
| Databáze: | OpenAIRE |
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