Extended amygdala-parabrachial circuits alter threat assessment and regulate feeding
| Autor: | Hannah Oden-Brunson, Robert W. Gereau, Abbie Sawyer, Andrew T. Luskin, Dionnet L. Bhatti, Kasey S. Girven, Kate Kimbell, Joseph D. Dougherty, Christian E. Pedersen, Michael R. Bruchas, Taylor Blackburn, Bernard Mulvey |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Multidisciplinary Parabrachial Nucleus Intrinsic drive Cognitive Neuroscience SciAdv r-articles Biology 03 medical and health sciences Stria terminalis 0302 clinical medicine Extended amygdala Biological neural network otorhinolaryngologic diseases Neuroscience Threat assessment 030217 neurology & neurosurgery Research Articles 030304 developmental biology Research Article |
| Zdroj: | Science Advances |
| ISSN: | 2375-2548 |
| Popis: | Circuit dissection techniques reveal that extended amygdala-brainstem circuitry integrates threat and feeding behavior. An animal’s evolutionary success depends on the ability to seek and consume foods while avoiding environmental threats. However, how evolutionarily conserved threat detection circuits modulate feeding is unknown. In mammals, feeding and threat assessment are strongly influenced by the parabrachial nucleus (PBN), a structure that responds to threats and inhibits feeding. Here, we report that the PBN receives dense inputs from two discrete neuronal populations in the bed nucleus of the stria terminalis (BNST), an extended amygdala structure that encodes affective information. Using a series of complementary approaches, we identify opposing BNST-PBN circuits that modulate neuropeptide-expressing PBN neurons to control feeding and affective states. These previously unrecognized neural circuits thus serve as potential nodes of neural circuitry critical for the integration of threat information with the intrinsic drive to feed. |
| Databáze: | OpenAIRE |
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