Cholinergic dysfunction, neurodegeneration, and amyloid-beta pathology in neurodegenerative diseases

Autor: Teodora Petrova, Lars-Olof Wahlund, Vesna Jelic, Birgitte Bo Andersen, Peter Høgh, Knut Engedal, Anne-Rita Oeksengaard, Daniel Ferreira, Camila Orellana, Mala Naik, Jon Snaedal
Rok vydání: 2020
Předmět:
Male
Pathology
Hippocampus
Cholinergic Antagonists
Cognition
0302 clinical medicine
Cerebrospinal fluid
Aged
80 and over
Cerebral Cortex
biology
Neurodegeneration
Brain
Electroencephalography
Neurodegenerative Diseases
Organ Size
Middle Aged
Mental Status and Dementia Tests
Magnetic Resonance Imaging
Psychiatry and Mental health
Biomarker (medicine)
Female
Lewy Body Disease
medicine.medical_specialty
Amyloid beta
Scopolamine
Neuroscience (miscellaneous)
tau Proteins
Diagnosis
Differential
03 medical and health sciences
Atrophy
Alzheimer Disease
mental disorders
medicine
Humans
Dementia
Radiology
Nuclear Medicine and imaging
Aged
Amyloid beta-Peptides
business.industry
Dementia with Lewy bodies
medicine.disease
Acetylcholine
030227 psychiatry
Cross-Sectional Studies
biology.protein
Cholinergic
business
Biomarkers
030217 neurology & neurosurgery
Zdroj: Psychiatry Research: Neuroimaging. 302:111099
ISSN: 0925-4927
DOI: 10.1016/j.pscychresns.2020.111099
Popis: Cholinergic dysfunction is central in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). The electroencephalography-based acetylcholine index (EEG-Ach index) has been proposed as a biomarker of cholinergic dysfunction. However, it is unclear how the EEG-Ach index relates to amyloid-beta pathology and neurodegeneration. We investigated the association between the EEG-Ach index and cerebrospinal fluid (CSF) amyloid-beta, CSF total tau, cortical thickness, and hippocampal volume from magnetic resonance imaging (MRI), and cognition. A total of 127 patients with different neurodegenerative diseases were studied. The EEG-Ach index was calculated from quantitative EEG using statistical pattern recognition. The EEG-Ach index was associated with hippocampal volume and cortical thickness in frontal, temporal, and occipital cortices. Cross-sectional sub-analyses based on a small sample suggests that the EEG-Ach index increases the closest to AD dementia, downstream to amyloid-beta pathology, CSF total tau, and hippocampal volume. We conclude that cholinergic dysfunction correlates with atrophy in brain areas important for AD pathogenesis, and this association is more prominent in the dementia stage. These results together with previous studies from this project suggest that the EEG-Ach index may be a useful biomarker for cholinergic dysfunction, with value for differential diagnosis of dementia and monitoring patients at the dementia stage.
Databáze: OpenAIRE
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