Locoregional Therapy Approaches for Hepatocellular Carcinoma: Recent Advances and Management Strategies
| Autor: | Mina S. Makary, Joshua D. Dowell, Khalid Mumtaz, Jordan M. Cloyd, Umang Khandpur |
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| Rok vydání: | 2020 |
| Předmět: |
radioembolization
Cancer Research medicine.medical_specialty Percutaneous Tare weight Review Disease Malignancy lcsh:RC254-282 ablation TARE 03 medical and health sciences 0302 clinical medicine transarterial embolization Transarterial embolization Advanced disease Medicine SIRT chemoembolization TACE business.industry hepatocellular carcinoma TAE lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Transplantation Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma 030211 gastroenterology & hepatology immunotherapy Radiology business |
| Zdroj: | Cancers Cancers, Vol 12, Iss 1914, p 1914 (2020) |
| ISSN: | 2072-6694 |
| Popis: | Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and third leading cause of cancer-related mortality worldwide. While surgical resection and transplantation are the standard first-line treatments for early-stage HCC, most patients do not fulfill criteria for surgery. Fortunately, catheter-directed and percutaneous locoregional approaches have evolved as major treatment modalities for unresectable HCC. Improved outcomes have been achieved with novel techniques which can be employed for diverse applications ranging from curative-intent for small localized tumors, to downstaging or bridging to resection and transplantation for early and intermediate disease, and locoregional control and palliation for advanced disease. This review explores recent advances in liver-directed techniques for HCC including bland transarterial embolization, chemoembolization, radioembolization, and ablative therapies, with a focus on patient selection, procedural technique, periprocedural management, and outcomes. |
| Databáze: | OpenAIRE |
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