Mechanisms of Antimicrobial Resistance (AMR) and Alternative Approaches to Overcome AMR
| Autor: | Swee-Hua-Erin Lim, Khatijah Yusoff, Warren Thomas, Aisha Abushelaibi, Mokrish Ajat, Chew-Li Moo, Shun-Kai Yang, Kok-Song Lai |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Drug Carriers Bacteria Computer science 030106 microbiology Bacterial Infections Antimicrobial Combined Modality Therapy Anti-Bacterial Agents 03 medical and health sciences 030104 developmental biology Antibiotic resistance Bacteriophage Therapy Risk analysis (engineering) Drug development Bacterial Proteins Biofilms Drug Resistance Multiple Bacterial Drug Discovery Humans Nanoparticles Drug Therapy Combination Phage Therapy Enzyme Inhibitors |
| Zdroj: | Current drug discovery technologies. 17(4) |
| ISSN: | 1875-6220 |
| Popis: | Antimicrobials are useful compounds intended to eradicate or stop the growth of harmful microorganisms. The sustained increase in the rates of antimicrobial resistance (AMR) worldwide is worrying and poses a major public health threat. The development of new antimicrobial agents is one of the critical approaches to overcome AMR. However, in the race towards developing alternative approaches to combat AMR, it appears that the scientific community is falling behind when pitched against the evolutionary capacity of multi-drug resistant (MDR) bacteria. Although the “pioneering strategy” of discovering completely new drugs is a rational approach, the time and effort taken are considerable, the process of drug development could instead be expedited if efforts were concentrated on enhancing the efficacy of existing antimicrobials through: combination therapies; bacteriophage therapy; antimicrobial adjuvants therapy or the application of nanotechnology. This review will briefly detail the causes and mechanisms of AMR as background, and then provide insights into a novel, future emerging or evolving strategies that are currently being evaluated and which may be developed in the future to tackle the progression of AMR. |
| Databáze: | OpenAIRE |
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