A family-based and case-control association study of the NOTCH4 gene and schizophrenia
| Autor: | Lin He, Yonglan Zheng, Niufan Gu, S. M. Zhu, Yangling Xing, L. P. Ji, Jun Xia Tang, F. G. Zou, D. St Clair, Jian Shi, Wanqing Liu, S. M. Zhao, Wensheng Sun, Gerome Breen, G. Y. Feng, Jinbo B Fan |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Linkage disequilibrium China Adolescent Genotype Single-nucleotide polymorphism Nerve Tissue Proteins Receptors Cell Surface Polymorphism Single Nucleotide Genetic determinism Linkage Disequilibrium Cellular and Molecular Neuroscience Proto-Oncogene Proteins Ethnicity Humans Genetic Predisposition to Disease Allele Receptor Notch4 Molecular Biology Alleles Genetics Receptors Notch Haplotype Case-control study Middle Aged Psychiatry and Mental health Haplotypes Case-Control Studies Schizophrenia Chromosomes Human Pair 6 Female Psychology Founder effect Microsatellite Repeats |
| Zdroj: | Molecular psychiatry. 7(1) |
| ISSN: | 1359-4184 |
| Popis: | Recently a strong positive association between schizophrenia and Notch4 has been reported. Both individual markers and haplotypes showed association with the disease, with five markers (three microsatellites and two SNPs) being tested. In order to test this finding we genotyped these markers in the Han Chinese population using a sample of 544 cases and 621 controls as well as >300 trios. Analysis of allele, genotype and haplotype frequencies in both samples showed no association between the markers and the disease. Our results would indicate that a significant role for the Notch4 gene in schizophrenia can be ruled out in the Han Chinese. However, similar studies are necessary in the Caucasian population as linkage disequilibrium arrangements and founder effects may differ between these two populations. |
| Databáze: | OpenAIRE |
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