Reduced Serum Cholesterol and Triglyceride Levels in a Choline-Deficient L-Amino Acid-Defined High-Fat Diet (CDAHFD)-Induced Mouse Model of Non-alcoholic Steatohepatitis (NASH)

Autor: Daisuke Yasuda, Haruki Torii, Rumiko Shimizu, Noriaki Kume, Yoshinori Hiraoka
Rok vydání: 2020
Předmět:
0301 basic medicine
CD36 Antigens
Male
medicine.medical_specialty
CD36
Pharmaceutical Science
Gene Expression
Diet
High-Fat
digestive system
Microsomal triglyceride transfer protein
Choline
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Non-alcoholic Fatty Liver Disease
Internal medicine
medicine
Animals
RNA
Messenger
Amino Acids
Abdominal obesity
Triglycerides
Pharmacology
chemistry.chemical_classification
biology
Triglyceride
business.industry
Tumor Necrosis Factor-alpha
Fatty liver
nutritional and metabolic diseases
Membrane Transport Proteins
General Medicine
medicine.disease
digestive system diseases
Amino acid
Choline Deficiency
Mice
Inbred C57BL
Disease Models
Animal
030104 developmental biology
Endocrinology
Cholesterol
chemistry
Liver
030220 oncology & carcinogenesis
biology.protein
medicine.symptom
Steatohepatitis
business
Zdroj: Biologicalpharmaceutical bulletin. 43(4)
ISSN: 1347-5215
Popis: Non-alcoholic fatty liver disease (NAFLD) or non-alcoholic seatohepatitis (NASH) is one of the major health problems world wide, because of increased abdominal obesity. To date, specific and effective medications to treat or prevent NAFLD/NASH have not been established. To identify appropriate molecular targets for that purpose, suitable animal models of NAFLD/NASH have been explored. A choline-deficient amino acid-defined high fat diet (CDAHFD)-induced mouse model of NASH has been developed. However, its relevance to human NASH, including serum lipid profiles, have not been clearly defined. In this study, we have revealed that mice fed CDAHFD showed significantly lowerd serum total cholesterol and triglyceride (TG) levels, in addition to reduced body weight (BW). Furthermore, hepatic microsomal triglyceride transfer protein (MTP) expression was significantly downregulated in CDAHFD-fed mice. Thus, the current CDAHFD-fed mouse model has points that are distinct from human NAFLD/NASH, in general, which is based upon abdominal obesity.
Databáze: OpenAIRE
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