Three-dimensional printing of anatomically accurate, patient specific intracranial aneurysm models
| Autor: | Walker L Thompson, Abdulaziz Alkattan, Robert G. Grossman, Jeff R. Anderson, Richard P. Klucznik, Christof Karmonik, Gavin W. Britz, Orlando M. Diaz, Yi J Zhang |
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| Rok vydání: | 2015 |
| Předmět: |
Models
Anatomic medicine.medical_specialty 3d printed Computer science Phase contrast microscopy Parent artery 030218 nuclear medicine & medical imaging law.invention Flow phantom 03 medical and health sciences 0302 clinical medicine Aneurysm law medicine Humans Retrospective Studies Fused deposition modeling Phantoms Imaging Angiography Digital Subtraction Intracranial Aneurysm General Medicine Patient specific medicine.disease Magnetic Resonance Imaging Surgery Three dimensional printing Printing Three-Dimensional Neurology (clinical) 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | Journal of NeuroInterventional Surgery. 8:517-520 |
| ISSN: | 1759-8486 1759-8478 |
| Popis: | ObjectiveTo develop and validate a method for creating realistic, patient specific replicas of cerebral aneurysms by means of fused deposition modeling.MethodsThe luminal boundaries of 10 cerebral aneurysms, together with adjacent proximal and distal sections of the parent artery, were segmented based on DSA images, and corresponding virtual three-dimensional (3D) surface reconstructions were created. From these, polylactic acid and MakerBot Flexible Filament replicas of each aneurysm were created by means of fused deposition modeling. The accuracy of the replicas was assessed by quantifying statistical significance in the variations of their inner dimensions relative to 3D DSA images. Feasibility for using these replicas as flow phantoms in combination with phase contrast MRI was demonstrated.Results3D printed aneurysm models were created for all 10 subjects. Good agreement was seen between the models and the source anatomy. Aneurysm diameter measurements of the printed models and source images correlated well (r=0.999; pConclusionsThe 3D printed aneurysm models presented were accurate and were able to be produced inhouse. These models can be used for previously cited applications, but their anatomical accuracy also enables their use as MRI flow phantoms for comparison with ongoing studies of computational fluid dynamics. Proof of principle imaging experiments confirm MRI flow phantom utility. |
| Databáze: | OpenAIRE |
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