Suspensão oral de rutina interfere na hiperplasia hepática em ratos
| Autor: | Pedro Paulo BARROS, André Bernardo de Camargo EISINGER, Gisele Mara Silva GONÇALVES, Gustavo Henrique da SILVA |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Fígado efeitos dos fármacos medicine.medical_treatment Rutin RC799-869 Hiperplasia 03 medical and health sciences chemistry.chemical_compound Ratos Wistar 0302 clinical medicine Oral administration Internal medicine Animals Hepatectomia Medicine Hepatectomy Aspartate Aminotransferases Rats Wistar Saline Hyperplasia biology business.industry Gastroenterology Alanine Transaminase Diseases of the digestive system. Gastroenterology medicine.disease Rats Liver drug effects Wistar rats Endocrinology Alanine transaminase chemistry Apoptosis 030220 oncology & carcinogenesis biology.protein Alkaline phosphatase 030211 gastroenterology & hepatology business Oral suspension Rutina |
| Zdroj: | Arquivos de Gastroenterologia v.57 n.3 2020 Arquivos de gastroenterologia Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia instacron:IBEPEGE Arquivos de Gastroenterologia, Vol 57, Iss 3, Pp 296-299 (2020) Arquivos de Gastroenterologia, Volume: 57, Issue: 3, Pages: 296-299, Published: 02 OCT 2020 |
| Popis: | BACKGROUND: Rutin is a flavonol glycoside that can be found in a wide variety of vegetables and has activity, anti-cancer, anti-inflammatory and anti-diabetic properties. OBJECTIVE: This study investigated the effect of rutin oral administration on Wistar rats submitted to hepatic hyperplasia after partial hepatectomy (PH). METHODS: To achieve this, we considered the analysis of hepatic hyperplastic and plasma biochemical activity of Wistar rats, subjected to treatment with rutin 40 mg/kg/day for 10 days in group 1 (G1) or saline in group 2 (G2), followed by partial hepatectomy. RESULTS: The results indicated an increase in the number of mitoses after 24 hours and 48 hours (P=0.0022 and P=0.0152, respectively) of PH in the group that received rutin, as well as an increase in AST serum levels after 24 hours (P=0.0159) and 48 hours (P=0.0158) and alkaline phosphatase after 24 hours (P=0.015) in the same group, in relation to the respective controls. The group that received rutin showed a more evident variation than the control group when comparing the 24 hour and 48 hour results regarding AST, number of mitoses and number of apoptosis (P |
| Databáze: | OpenAIRE |
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