Interference of ascorbic acid in the sensitive detection of dopamine by a nonoxidative sensing approach
| Autor: | Yetunde Balogun, Yufeng Ma, Shah R. Ali, Huixin He, Rishi R. Parajuli |
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| Rok vydání: | 2007 |
| Předmět: |
inorganic chemicals
Aniline Compounds Nanotubes Carbon Ligand binding assay Dopamine Diol Ascorbic Acid Ascorbic acid Electrochemistry Boronic Acids Surfaces Coatings and Films chemistry.chemical_compound Transduction (biophysics) chemistry Polyaniline Materials Chemistry medicine Organic chemistry Physical and Theoretical Chemistry Oxidation-Reduction Boronic acid medicine.drug |
| Zdroj: | The journal of physical chemistry. B. 111(42) |
| ISSN: | 1520-6106 |
| Popis: | The electrochemistry of a poly(anilineboronic acid)/carbon nanotube composite was studied in the presence of dopamine and ascorbic acid. To understand the binding affinity of dopamine and ascorbic acid to the boronic acid functional groups in the composite, the association constants between the diol groups in dopamine and ascorbic acid and the boronic acid were experimentally determined using a fluorescence-based binding assay. The results demonstrate that ascorbic acid could severely interfere with the detection of dopamine in nonoxidative boronic acid-binding approaches: Ascorbic acid was able to electrocatalytically reduce the fully oxidized polyaniline backbone during the electrochemical oxidation process; similarly to dopamine, ascorbic acid was also able to bind to the boronic acid groups through its planar diol group even though the binding affinity is much lower. The examination of the dopamine transduction mechanism and ascorbic acid interference mechanism in this nonoxidative approach will benefit the design of future boronic acid-based sensors. |
| Databáze: | OpenAIRE |
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