Urinary transferrin and proinflammatory markers predict the earliest diabetic nephropathy onset

Autor:	Samia A. Ahmed, Wessam M. Aziz, Sylvia E. Shaker, Dalia B. Fayed, Heba Shawky
Rok vydání:	2022
Předmět:	Male ROC Curve Health Toxicology and Mutagenesis Clinical Biochemistry Diabetes Mellitus Transferrin Animals Humans Diabetic Nephropathies Rats Wistar Biochemistry Biomarkers Rats
Zdroj:	Biomarkers. 27:178-187
ISSN:	1366-5804 1354-750X
Popis:	This study aimed to determine the earliest markers of diabetic nephropathy (DN) onset with discriminative potentials from controlled diabetes (CD).Sixty male Wistar rats were allocated into three groups (20/group), the two diabetic groups CD and DN received 45 and 65 mg/kg STZ in 0.1 mole/L citrate buffer, respectively, while the control group received only the vehicle. Serum/urinary levels of glomerular, tubular, oxidative and proinflammatory markers were weekly monitored.Each diabetic group showed a different pattern of inflammatory, oxidative and signs of nephropathy along the study period, but none had a discriminative power until the fourth week. At this time point, levels of urinary transferrin, serum/urinary IL-6 and TNF-α as well as urinary IL-18 were significantly higher in DN group compared to CD (Urinary transferrin and the inflammatory endpoints proposed in this study might represent promising biomarkers for the early DN onset.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c4a63f3995a2e33d76c02b4790cb93 https://doi.org/10.1080/1354750x.2021.2023639 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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