| Autor: |
Mi Seon Han, Jihye Um, Eun Joo Lee, Kyung Min Kim, Sung Hee Chang, Hyunju Lee, Ye Kyung Kim, Youn Young Choi, Eun Young Cho, Dong Hyun Kim, Jae Hong Choi, Jina Lee, Misuk Kim, Ki-Hyun Chung, Hye Sook Min, Young June Choe, Dong-Gyun Lim, Jun-Sun Park, Eun Hwa Choi |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of the Pediatric Infectious Diseases Society. 11:267-273 |
| ISSN: |
2048-7207 |
| DOI: |
10.1093/jpids/piac012 |
| Popis: |
Background The immunologic features of children with coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not clearly delineated. This study was conducted to evaluate SARS-CoV-2-specific antibody responses in children with COVID-19. Methods The levels of anti-spike (S) IgG, anti-SARS-CoV-2 IgG, and neutralizing antibody (NAb) were measured during various time points in children Results One hundred sixty-five blood samples from 114 children with COVID-19 (43.9% asymptomatic and 56.1% mildly symptomatic) were analyzed. In both asymptomatic and mildly symptomatic children, the positive rates of anti-S IgG, anti-SARS-CoV-2 IgG, and NAb were low within 7 days after onset, but they soon reached 100% 14 to Conclusions These results collectively present the humoral immune responses during SARS-CoV-2 infection in children. A further longitudinal study is needed to thoroughly understand the immune system and for effective vaccine development in children during the COVID-19 pandemic. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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