Unfolding the Role of Splicing Factors and RNA Debranching in AID Mediated Antibody Diversification
| Autor: | Ankit Jaiswal, Prashant Kodgire, Amit Kumar Singh, Anubhav Tamrakar |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Immunology Immunoglobulins Somatic hypermutation Cell Cycle Proteins chemical and pharmacologic phenomena Biology 03 medical and health sciences 0302 clinical medicine Antibody Repertoire Cytidine Deaminase Humans Immunology and Allergy Genetics Tumor Suppressor Proteins RNA-Binding Proteins RNA Immunoglobulin Class Switching DNA-Binding Proteins 030104 developmental biology Immunoglobulin class switching 030220 oncology & carcinogenesis RNA splicing biology.protein RNA Splicing Factors Antibody |
| Zdroj: | International Reviews of Immunology. 40:289-306 |
| ISSN: | 1563-5244 0883-0185 |
| Popis: | Activated B-cells diversify their antibody repertoire via somatic hypermutation (SHM) and class switch recombination (CSR). SHM is restricted to the variable region, whereas, CSR is confined to the constant region of immunoglobulin ( |
| Databáze: | OpenAIRE |
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