A stonemason with accelerated silicosis in the setting of tumour necrosis factor alpha inhibitor therapy
| Autor: | Andrew Dettrick, Michael Putt, Timothy Baird |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine business.industry Lung fibrosis Silicosis Interstitial lung disease Case Report Case Reports Tumour necrosis factor alpha medicine.disease Pathogenesis stonemason 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030228 respiratory system Psoriasis Immunology TNF‐alpha inhibitor medicine Adalimumab Occupational lung disease business medicine.drug |
| Zdroj: | Respirology Case Reports |
| ISSN: | 2051-3380 |
| Popis: | We present the case of a 26‐year‐old stonemason with accelerated silicosis in the setting of treatment for psoriasis with the tumour necrosis factor alpha (TNF‐alpha) inhibitor adalimumab. Accelerated silicosis is an important occupational lung disease with a poor prognosis and limited treatment options [1]. Although the exact pathogenesis remains unknown, it is suggested that secretion of cytokines, including TNF‐alpha, plays a central role in disease progression [1,2]. Importantly, however, TNF‐alpha inhibitors, in addition to resulting in an increased risk of infection, are also now being seen to cause interstitial lung disease [3,4]. To our knowledge, this is the first documented patient to develop silicosis whilst on TNF‐alpha inhibitor therapy. This case challenges the theory behind TNF‐alpha's exact role in the pathogenesis of silicosis and lung fibrosis, highlights the importance of monitoring individuals with both occupational and drug exposures, and illustrates the increasing difficulties physicians face in investigating patients with pulmonary infiltrates and multiple possible aetiologies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|