Expression of the Dan gene during chicken embryonic development
| Autor: | Junko Ogita, Eriko Isogai, Hidefumi Sudo, Haruhiko Koseki, Shigeru Sakiyama, Akira Nakagawara |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Embryology
DNA Complementary Time Factors animal structures Tumor suppressor gene Xenopus Molecular Sequence Data Cell Cycle Proteins Chick Embryo Xenopus Proteins Bone morphogenetic protein Cerberus (protein) Paraxial mesoderm Animals Humans Tissue Distribution Amino Acid Sequence In Situ Hybridization Genetics Sequence Homology Amino Acid biology Embryogenesis Proteins Bone morphogenetic protein 10 biology.organism_classification Cell biology Protein Biosynthesis embryonic structures Gremlin (protein) Developmental Biology |
| Zdroj: | Mechanisms of Development. 109(2):363-365 |
| ISSN: | 0925-4773 |
| DOI: | 10.1016/s0925-4773(01)00522-6 |
| Popis: | The Dan gene was first identified as the putative rat tumor suppressor gene and encodes a protein structurally related to Cerberus and Gremlin in vertebrates. Xenopus DAN, as with Cerberus and Gremlin, was demonstrated to block bone morphogenetic protein (BMP) signaling by binding BMPs, and to be capable of inducing additional anterior structures by ectopic overexpression in Xenopus embryos. DAN, thus, is suggested to play pivotal roles in early patterning and subsequent organ development, as in the case of other BMP antagonists. In this report, we isolated the chicken counterpart of Dan. Chicken Dan is mainly expressed in the cephalic and somitic mesoderm and several placodes during organ development. |
| Databáze: | OpenAIRE |
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