Uncaria tomentosa extract (AC-11) improves pregnancy hypertension together with suppression of sFlt-1 and sEng
| Autor: | Hironori Takahashi, Ren Ozawa, Riina Shinoda, Hisataka Iwata, Yasushi Torii, Kai Seshima, Takehito Kuwayama, Koumei Shirasuna, Yuka Oogaki |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_treatment
Population Inflammation Blood Pressure Pharmacology Uncaria tomentosa Extract Umbilical vein Mice Pre-Eclampsia Pregnancy Placenta Internal Medicine Uncaria tomentosa medicine Animals Humans Cat's Claw education education.field_of_study Vascular Endothelial Growth Factor Receptor-1 biology business.industry Plant Extracts Endoglin Obstetrics and Gynecology biology.organism_classification Angiotensin II medicine.anatomical_structure Cytokine Female medicine.symptom business |
| Zdroj: | Pregnancy hypertension. 26 |
| ISSN: | 2210-7797 |
| Popis: | Disruption of well-controlled reproductive functions leads to pregnancy complications such as hypertensive disorders of pregnancy (HDP). Uncaria tomentosa (Wild), known as cat’s claw, is widely used for the treatment of a various types of health problems; AC-11 (AC-11®, hot-water extract of U. tomentosa) is unique phytochemical compound and has potential roles as anti-inflammatory or anti-oxidant processes. We investigated whether AC-11 has a protective effect on pathogenesis of HDP in vivo and production of anti-angiogenic factors (sFlt-1 and sEng, major factors for the onset of HDP) in in vitro. Non-pregnant or pregnant mice were administered AC-11 (4 mg/mL), then, angiotensin II (Ang II) was subcutaneously infused to increase blood pressure. Human placental tissues or human umbilical vein endothelial cells (HUVECs) were incubated with or without AC-11. Treatment with AC-11 significantly reduced blood pressure induced by Ang II infusion. The population of CD8+T cells, the ratio of CD8/CD4, and plasma interleukin-6 levels were increased by Ang II infusion, and were decreased by AC-11 both in pregnant and non-pregnant mice. In pregnant mice, plasma levels of sFlt-1 and sEng were decreased by AC-11. In in vitro cell culture of HUVECs or placental tissue culture, treatment with AC-11 significantly inhibited secretion of sFlt-1 and sEng. We suggest a novel role of AC-11 in regulating blood pressure by controlling the balance of T cell population and inflammatory cytokine production both in non-pregnant and pregnant conditions. In addition, AC-11 inhibits HDP-related factors, including sFlt-1 and sEng, suggesting that AC-11 may useful for relieving HDP. |
| Databáze: | OpenAIRE |
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