The Relationship between Circulating Polyunsaturated Fatty Acid Levels and Exercise Responses of Patients with Non-ischemic Heart Failure
| Autor: | Takahiro Muroya, Tetsufumi Motokawa, Tsuyoshi Yonekura, Yosuke Morimoto, Satoshi Ikeda, Yudai Yano, Seiya Izumida, Ryohei Akashi, Koji Maemura, Hiroaki Kawano |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.drug_class Coronary artery disease chemistry.chemical_compound Young Adult Internal medicine Internal Medicine Natriuretic peptide Medicine Humans Exercise Aged chemistry.chemical_classification Aged 80 and over Heart Failure business.industry General Medicine Middle Aged medicine.disease Eicosapentaenoic acid Exercise Therapy nutrition chemistry Docosahexaenoic acid Heart failure Cardiology Exercise Test Fatty Acids Unsaturated Arachidonic acid lipids (amino acids peptides and proteins) Original Article Female business diet human activities Respiratory minute volume cardiopulmonary exercise test Polyunsaturated fatty acid |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | Objective Polyunsaturated fatty acids (PUFAs) are associated with heart failure (HF) as well as coronary artery disease. However, little is known about the relationships between PUFAs and the exercise responses of patients with HF. We evaluated the relationships between PUFAs and the parameters of cardiopulmonary exercise tests (CPETs) in patients with non-ischemic HF. Methods Fifty patients with stable non-ischemic HF underwent CPETs at our hospital. Data were analyzed to evaluate the relationships between PUFAs and echocardiographic findings as well as CPET and other test parameters. Results Correlations were significant and negative between dihomo-γ-linolenic acid (DGLA) + arachidonic acid (AA) and minute ventilation versus carbon dioxide production (VE/VCO2) slope, and positive between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and VE/VCO2 slope. A multivariate regression analysis selected DGLA+AA and AA as independent predictors of VE/VCO2 slope. However, eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) were not significantly correlated with the CPET parameters. Conclusion Low levels of circulating DGLA+AA and AA among PUFAs were associated with decreased exercise responses in patients with stable non-ischemic HF. These findings suggest that high levels of omega-6 PUFAs may improve the clinical outcomes of patients with non-ischemic HF via their effects on exercise responses. Internal Medicine, 58(22), pp.3219-3225; 2019 |
| Databáze: | OpenAIRE |
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