Response to Glucocorticoid Therapy in Patients with Mild to Moderate Coronavirus Disease 2019 at a Japanese Care Facility

Autor: Akiko Kikuchi, Ryutaro Arita, Rie Ono, Yasunori Tadano, Natsumi Saito, Tetsuya Akaishi, Takeshi Kanno, Minoru Osawa, Shin Takayama, Michiaki Abe, Ko Onodera, Tadashi Ishii
Rok vydání: 2022
Předmět:
Zdroj: The Tohoku journal of experimental medicine. 257(2)
ISSN: 1349-3329
Popis: The fifth wave of the coronavirus disease 2019 (COVID-19) pandemic caused by delta variant infection depleted medical resources, and the Japanese government announced glucocorticoid use for outpatients. An appropriate outpatient-glucocorticoid treatment for COVID-19 has not been established; therefore, we created treatment manuals with indications for glucocorticoid administration in a care facility adequately equipped to manage patients with mild to moderate COVID-19. Thirty-eight patients (24 males, 14 females; mean age 40.5 ± 11.8 years) were treated with glucocorticoids from August 1 to October 1, 2021 [COVID-19 staging, mild (n = 1), moderate I (n = 19), and moderate II (n = 18)]. Patients were treated with 6.6 mg/day d.i.v. or 6 mg/day p.o. dexamethasone, or 20-30 mg/day p.o. prednisolone. The median (25
Databáze: OpenAIRE