Hematological indices as indicators of silent inflammation in achalasia patients: A cross-sectional study
| Autor: | Enrique Coss-Adame, Miguel A. Valdovinos, Angel Priego-Ranero, Hector Olvera-Prado, Sofia Narvaez-Chavez, Gonzalo Torres-Villalobos, Fernanda Romero-Hernández, Janette Furuzawa-Carballeda, Fidel Lopez-Verdugo, Jose Peralta-Figueroa |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Cross-sectional study Achalasia Observational Study hematologic indices Logistic regression Gastroenterology 03 medical and health sciences 0302 clinical medicine neutrophil-to-lymphocyte ratio Psoriasis Internal medicine otorhinolaryngologic diseases Medicine Humans 030212 general & internal medicine Mexico Inflammation medicine.diagnostic_test business.industry fungi Area under the curve Complete blood count General Medicine Esophageal cancer Middle Aged medicine.disease Healthy Volunteers Blood Cell Count Esophageal Achalasia achalasia Cross-Sectional Studies 030220 oncology & carcinogenesis Rheumatoid arthritis biomarker Female business Biomarkers Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Complete blood count (CBC)-derived parameters such as neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), eosinophil-to-lymphocyte (ELR) ratio, and platelet-to-lymphocyte ratio (PLR) are sensitive markers of occult inflammation and disease activity for systemic lupus erythematosus, rheumatoid arthritis, psoriasis, esophageal cancer, etc. We assessed NLR, PLR, MLR, and ELR as indicators of inflammation in achalasia patients. This cross-sectional study included 103 achalasia patients and 500 healthy blood donor volunteers (HD). Demographic, clinical and laboratory information was collected. NLR, MLR, ELR and PLR were calculated. Peripheral Th22, Th17, Th2 and Th1 subsets were determined by flow cytometry. Correlation between hematologic indices and clinical questionnaires scores, HRM parameters and CD4+ T-cells were assessed. Hematologic parameters associated with the different achalasia subtypes were evaluated by logistic regression analysis. Hemoglobin, leukocytes, lymphocytes, monocytes, and platelets counts were significantly lower in achalasia patients vs controls. NLR (P = .006) and ELR (P |
| Databáze: | OpenAIRE |
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