Significant improvement of facial actinic keratoses after blue light photodynamic therapy with oral vitamin D pretreatment: An interventional cohort-controlled trial

Autor:	Taylor A. Bullock, Jeffrey Negrey, Bo Hu, Christine B. Warren, Tayyaba Hasan, Edward V. Maytin
Rok vydání:	2022
Předmět:	Keratosis Actinic Mice Photosensitizing Agents Treatment Outcome Photochemotherapy Animals Humans Aminolevulinic Acid Vitamins Dermatology Vitamin D Article
Zdroj:	J Am Acad Dermatol
ISSN:	0190-9622
DOI:	10.1016/j.jaad.2022.02.067
Popis:	BACKGROUND: In mouse skin cancer models, high-dose oral vitamin D3 (VD3; cholecalciferol) combined with photodynamic therapy (PDT) can improve the clearance of squamous precancers (actinic keratoses, AK). OBJECTIVE: To determine whether oral VD3 can improve clinical efficacy of a painless PDT regimen in humans with AK. METHODS: Baseline lesion counts and serum 25OH-D3 levels were obtained. In one cohort (Group 1), 29 patients received gentle debridement and 15-min ALA preincubation followed by blue light (30 min; 20 J/cm(2)). In Group 2, 29 patients took oral VD3 (10,000 IU daily, 5 or 14 days) prior to the debridement/PDT. Lesion clearance was assessed at 3–6 months. RESULTS: In Group 1, mean clearance rates (CR) of facial AK were lower in patients with VD3 deficiency (25OH-D3
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89bebff1b8f52964bd3040fbc5db8dea https://doi.org/10.1016/j.jaad.2022.02.067 Zobrazit plný text záznamu Full Text from ScienceDirect