Perinatal BPA exposure alters body weight and composition in a dose specific and sex specific manner: The addition of peripubertal exposure exacerbates adverse effects in female mice
| Autor: | Maneesha Paranjpe, Andrew S. Greenberg, Cheryl M. Schaeberle, Martin S. Obin, Tracey DaFonte, Beverly S. Rubin, Ana M. Soto |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty endocrine system Aging 010501 environmental sciences Toxicology Body weight 01 natural sciences Article 03 medical and health sciences chemistry.chemical_compound Mice Sex Factors Phenols Pregnancy Internal medicine medicine Animals Benzhydryl compounds Benzhydryl Compounds Adverse effect 0105 earth and related environmental sciences Perinatal Exposure Dose-Response Relationship Drug business.industry urogenital system Body Weight medicine.disease Sex specific Obesity 030104 developmental biology Endocrinology chemistry Prenatal Exposure Delayed Effects Body Composition Composition (visual arts) Environmental Pollutants Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Reproductive toxicology (Elmsford, N.Y.). 68 |
| ISSN: | 1873-1708 |
| Popis: | Body weight (BW) and body composition were examined in CD-1 mice exposed perinatally or perinatally and peripubertally to 0, 0.25, 2.5, 25, or 250 μg BPA/kg BW/day. Our goal was to identify the BPA dose (s) and the exposure window(s) that increased BW and adiposity, and to assess potential sex differences in this response. Both perinatal exposure alone and perinatal plus peripubertal exposure to environmentally relevant levels of BPA resulted in lasting effects on body weight and body composition. The effects were dose specific and sex specific and were influenced by the precise window of BPA exposure. The addition of peripubertal BPA exposure following the initial perinatal exposure exacerbated adverse effects in the females but appeared to reduce differences in body weight and body composition between control and BPA exposed males. Some effects of BPA on body weight and body composition showed a non-linear dose response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect