Assessment and clinical relevance of the dynamic parameters of ventricular repolarization in patients with grade I left ventricular diastolic dysfunction
| Autor: | José Sobral Neto, Melchior Luiz Lima, Tânia Maria de Andrade Rodrigues, Antoinette Oliveira Blackman, Otoni Moreira Gomes |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Ventricular Repolarization Physiology Heart Ventricles 030204 cardiovascular system & hematology Sudden cardiac death 03 medical and health sciences Electrocardiography Ventricular Dysfunction Left 0302 clinical medicine Diastole Physiology (medical) Internal medicine Medicine Humans In patient Clinical significance 030212 general & internal medicine Pharmacology business.industry General Medicine Middle Aged medicine.disease Increased risk Cardiology Left ventricular diastolic dysfunction Female business |
| Zdroj: | Canadian journal of physiology and pharmacology. 97(6) |
| ISSN: | 1205-7541 |
| Popis: | Imbalance in ventricular repolarization parameters are related to increased risk of severe arrhythmia and sudden cardiac death. There is limited research regarding markers to detect patients at risk in this early stage. We aimed to assess the influence of grade I left ventricular diastolic dysfunction on repolarization parameters in asymptomatic patients. Ambulatory patients with grade I left ventricular diastolic dysfunction were studied and compared with a control group. We assessed the QT dispersion circadian variation, heart rate variability in the time and frequency domains, and dynamics of QT using a 12-lead Holter. In the diastolic dysfunction group, 8 (30%) patients had QT dispersion > 80 ms. One (3.8%) patient presented premature ventricular complex > 10/h. The comparison between the 2 groups showed that the difference between the standard deviation of normal-to-normal intervals and low frequency power in both groups was statistically significant. We therefore conclude that increased parameters of ventricular repolarization and depressed heart rate variability reflect an imbalance in autonomic responses in patients with grade I left ventricular diastolic dysfunction without cardiovascular symptoms, enabling the identification of patients that are at a higher risk for cardiovascular events. |
| Databáze: | OpenAIRE |
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